The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness
Figure 2
Electron micrographs of outer retina showing photoreceptor outer and inner segments of normal (a) Abyssinian cat and young affected (b) rdAc cat. Note abnormalities at the base of the rod outer segments near the connecting cilium in (b); membranes are not formed as in the normal (a), instead there is vacuolization and degeneration (arrows) of membranes in the affected retina. Am: apical microvilli of the retinal pigment epithelium, ros: rod outer segments, ris: rod inner segments, cos: cone outer segments, cis: cone inner segments, cc: connecting cilium of the photoreceptor. Original magnification: ×19152. Reproduced with permission from [27].
