Table 3: Systemic drugs probably causing or aggravating dry eyes [13].

ClassExamples

Antihypertensive agents (beta-agonists)Acebutolol
Antihypertensive agent (alpha-agonists)Atenolol
Antiarrhythmic agents (beta blockers)Carvedilol
Labetalol
Metoprolol
Nadolol
Pindolol
Clonidine
Prazosin
Oxprenolol
Propranolol

Antipsychotic agentsChlorpromazine
Fluphenazine
Lithium carbonate
Perphenazine
Prochlorperazine
Promethazine
Quetiapine
Thiethylperazine
Thioridazine
Brompheniramine
Carbinoxamine
Chlorphenamine (chlorpheniramine)
Clemastine
Cyproheptadine
Dexchlorpheniramine

BronchodilatorsDiphenhydramine
Antispasmodics/ antimuscarinicDoxylamine
Antiarrythmic agentsIpratropium
Atropine
Homatropine
Tolterodine
Hyoscine (scopolamine)
Hyoscine methobromide (methscopolamine)
Disopyramide

Antineoplastic agentsBusulfan
Cyclophosphamide
Interferon (alpha, beta, gamma, or PEG)
Vinblastine
Cetuximab
Erlotinib
Gefitinib

AntihistaminesCetirizine
Desloratadine
Fexofenadine
Loratadine
Olopatadine
Tripelennamine

AntidepressantsCitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

Antileprosy agentsClofazimine

Antirheumatic agents/analgesicsAspirin
Ibuprofen

Sedatives and hypnoticsPrimidone

Drugs secreted in tearsAspirin
Chloroquine
Clofazimine
Docetaxel
Ethyl alcohol
Hydroxychloroquine
Ibuprofen
Isotretinoin

AntiandrogensTamsulosin
Terazosin
Doxazosin
Alfuzosin

NeurotoxinsBotulinum A or B toxin

Antimalarial agentsChloroquine
Hydroxychloroquine

RetinoidsIsotretinoin

AntiviralAciclovir

ThiazidesBendroflumethiazide
Chlorothiazide
Chlortalidone
Hydrochlorothiazide
Hydroflumethiazide
Indapamide
Methyclothiazide
Metolazone
Polythiazide
Trichlormethiazide

CannabinoidsDronabinol
Hashish
Marijuana

Chelating agentsMethoxsalen

Strong analgesicsMorphine
Opium/opioids

Antipsychotic agentsPimozide

References for the above systemic medications provided at http://www.eyedrugregistry.com/.