Adverse Effects of Systemic Immunosuppression in Keratolimbal Allograft

Table 2

Adverse effects of systemic immunosuppression.

Frequency (Number of patients)	Adverse effect (level)	Adverse effect status
2	Elevated transaminases and hyperbilirubinemia (8.6, 3.8)	Resolved by switching azathioprine to mycophenolate; not completely resolved possibly from alcohol abuse
2	Elevated creatinine (1.5, 1.6)	Resolved after reducing/discontinuing tacrolimus
3	Hyperglycemia	Treated with insulin; resolved by increasing oral hypoglycemic medication
2	Anemia (Hgb 11.9, 10.9)	Resolved with vitamin B12; resolved with multivitamin
1	Hypomagnesemia (1.6)	Self-resolved
1	Worsening hypertension	Resolved with increased medication
1	Thrombocytopenia (89)	Not yet resolved, possibly from alcohol abuse
1	Acne	Resolved after tapering off prednisone and tacrolimus
1	Headache, tremors	Resolved by decreasing tacrolimus
1	HSV keratitis	Resolved with oral acyclovir
1	Osteopenia	Did not resolve