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Journal of Ophthalmology
Volume 2012 (2012), Article ID 642869, 5 pages
http://dx.doi.org/10.1155/2012/642869
Clinical Study

Baseline Factors Predictive of SLT Response: A Prospective Study

1Department of Ophthalmology, University of Montreal, Montreal, QC, Canada
2Maisonneuve-Rosemont Hospital Research Centre, Montreal, QC, Canada

Received 25 February 2012; Accepted 13 May 2012

Academic Editor: Andrew G. Lee

Copyright © 2012 Robin Bruen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To study the response to Selective Laser Trabeculoplasty (SLT) according to baseline medical treatment, angle pigmentation, age, diagnosis (open-angle glaucoma or ocular hypertension), and baseline intraocular pressure (IOP). Methods. 74 eyes of 74 patients were enrolled in this study. Baseline characteristics were recorded for each patient. IOP in the treated and fellow eyes was measured at baseline, and 1 month, 6 months, and 12 months following SLT. IOP changes in the different groups were compared using two-way ANOVA and Pearson's correlation. Results. The mean age of our cohort was 7 1 ± 1 0 years. The mean baseline IOP was 2 1 . 5 ± 5  mmHg, and the mean change in IOP from baseline in the treated eye at one year was 4 . 6 7 ± 3 . 4 0  mmHg. Higher baseline IOP was highly correlated with greater absolute IOP decrease. Prostaglandin analogue use at baseline was shown to be associated with a statistically decreased IOP-lowering response following SLT when corrected for baseline IOP. No significant differences in IOP response were found when comparing groups stratified for age, angle pigmentation, phakic status, gender, or diagnosis. Discussion. The results of this study confirm the finding that higher baseline IOP is a predictor of greater IOP response following SLT, and that pretreatment with prostaglandin analogue therapy is associated with a decreased IOP-lowering response following SLT. The study is limited by the small number of eyes with data available for complete case analysis.