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Journal of Ophthalmology
Volume 2013 (2013), Article ID 257381, 5 pages
http://dx.doi.org/10.1155/2013/257381
Clinical Study

Aqueous Concentrations of Vascular Endothelial Growth Factor in Eyes with High Myopia with and without Choroidal Neovascularization

1Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
2Department of Biomedical statistics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan

Received 25 June 2012; Accepted 1 February 2013

Academic Editor: Edward Manche

Copyright © 2013 Taku Wakabayashi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Xu, Y. Wang, Y. Li et al., “Causes of blindness and visual impairment in urban and rural areas in Beijing: the Beijing Eye Study,” Ophthalmology, vol. 113, no. 7, pp. 1134.e1–1134.e11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Iwase, M. Araie, A. Tomidokoro, T. Yamamoto, H. Shimizu, and Y. Kitazawa, “Prevalence and causes of low vision and blindness in a Japanese adult population: the Tajimi study,” Ophthalmology, vol. 113, no. 8, pp. 1354–1362, 2006. View at Scopus
  3. C. C. Klaver, R. C. Wolfs, J. R. Vingerling, et al., “Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam study,” Archives of Ophthalmology, vol. 116, no. 5, pp. 653–658, 1998. View at Scopus
  4. S. A. Cotter, R. Varma, M. Ying-Lai, S. P. Azen, and R. Klein, “Causes of low vision and blindness in adult Latinos: the Los Angeles Latino Eye study,” Ophthalmology, vol. 113, no. 9, pp. 1574–1582, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Yoshida, K. Ohno-Matsui, K. Yasuzumi et al., “Myopic choroidal neovascularization: a 10-year follow-up,” Ophthalmology, vol. 110, no. 7, pp. 1297–1305, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Otani, H. Takagi, H. Oh, S. Koyama, M. Matsumura, and Y. Honda, “Expressions of angiopoietins and Tie2 in human choroidal neovascular membranes,” Investigative Ophthalmology and Visual Science, vol. 40, no. 9, pp. 1912–1920, 1999. View at Scopus
  7. J. Tong, W. Chan, D. T. L. Liu et al., “Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization,” American Journal of Ophthalmology, vol. 141, no. 3, pp. 456–462, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Sakaguchi, Y. Ikuno, F. Gomi, et al., “Intravitreal injection of bevacizumab for choroidal neovascularisation associated with pathological myopia,” British Journal of Ophthalmology, vol. 91, no. 2, pp. 161–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Yamamoto, A. H. Rogers, E. Reichel, P. A. Yates, and J. S. Duker, “Intravitreal bevacizumab (Avastin) as treatment for subfoveal choroidal neovascularisation secondary to pathological myopia,” British Journal of Ophthalmology, vol. 91, no. 2, pp. 157–160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Chan, T. Y. Y. Lai, D. T. L. Liu, and D. S. C. Lam, “Intravitreal bevacizumab (Avastin) for myopic choroidal neovascularization: six-month results of a prospective pilot study,” Ophthalmology, vol. 114, no. 12, pp. 2190–2196, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Gharbiya, F. Allievi, L. Mazzeo, and C. B. Gabrieli, “Intravitreal bevacizumab treatment for choroidal neovascularization in pathologic myopia: 12-month results,” American Journal of Ophthalmology, vol. 147, no. 1, pp. 84.e1–93.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Ikuno, K. Sayanagi, K. Soga et al., “Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results,” American Journal of Ophthalmology, vol. 147, no. 1, pp. 94.e1–100.e1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Wakabayashi, Y. Ikuno, F. Gomi, T. Hamasaki, and Y. Tano, “Intravitreal bevacizumab vs sub-tenon triamcinolone acetonide for choroidal neovascularization attributable to pathologic myopia,” American Journal of Ophthalmology, vol. 148, no. 4, pp. 591–596, 2009. View at Scopus
  14. W. Chan, T. Y. Y. Lai, K. Chan et al., “Changes in aqueous vascular endothelial growth factor and pigment epithelial-derived factor levels following intravitreal bevacizumab injections for choroidal neovascularization secondary to age-related macular degeneration or pathologic myopia,” Retina, vol. 28, no. 9, pp. 1308–1313, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Ikuno and Y. Tano, “Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography,” Investigative Ophthalmology and Visual Science, vol. 50, no. 8, pp. 3876–3880, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. L. P. Aiello, A. J. Brucker, S. Chang et al., “Evolving guidelines for intravitreous injections,” Retina, vol. 24, supplement 5, pp. S3–S19, 2004. View at Scopus
  17. A. P. Dempster, N. M. Laird, and D. B. Rubin, “Maximum likelihood from incomplete data via the EM algorithm (with discussion),” Journal of the Royal Statistical Society B, vol. 39, no. 1, pp. 1–38, 1977.
  18. M. S. Wolynetz, “Maximum likelihood estimation from confined and censored normal data,” Applied Statistics, vol. 28, pp. 185–195, 1979.
  19. L. P. Aiello, R. L. Avery, P. G. Arrigg et al., “Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders,” The New England Journal of Medicine, vol. 331, no. 22, pp. 1480–1487, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. A. P. Adamis, J. W. Miller, M. T. Bernal, et al., “Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy,” American Journal of Ophthalmology, vol. 118, no. 4, pp. 445–450, 1994. View at Scopus
  21. A. Kvanta, P. V. Algvere, L. Berglin, and S. Seregard, “Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor,” Investigative Ophthalmology and Visual Science, vol. 37, no. 9, pp. 1929–1934, 1996. View at Scopus
  22. R. C. Tripathi, J. Li, B. J. Tripathi, Chalam, and A. P. Adamis, “Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma,” Ophthalmology, vol. 105, no. 2, pp. 232–237, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. O. Sawada, H. Kawamura, M. Kakinoki, T. Sawada, and M. Ohji, “Vascular endothelial growth factor in aqueous humor before and after intravitreal injection of bevacizumab in eyes with diabetic retinopathy,” Archives of Ophthalmology, vol. 125, no. 10, pp. 1363–1366, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. J. Tolentino, J. W. Miller, E. S. Gragoudas, K. Chatzistefanou, N. Ferrara, and A. P. Adamis, “Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate,” Archives of Ophthalmology, vol. 114, no. 8, pp. 964–970, 1996. View at Scopus
  25. S. Duke-Elder, “Pathological refractive errors,” in System of Ophthalmology, vol. 5 of Ophthalmic Optics and Refraction, pp. 297–373, Mosby, St. Louis, Mo, USA, 1970.
  26. H. Ohno, “Electron microscopic studies of myopic retinochoroidal atrophies 1. Choroidal changes,” Folia Ophthalmologica Japonica, vol. 43, pp. 1244–1253, 1983 (Japanese).
  27. N. Matsuo, S. Okabe, E. Hasegawa, and S. Okamoto, Report of Research Committee on Chorioretinal Degenerations, The Ministry of Health and Welfare of Japan, Tokyo, Japan, (Japanese), 1978.
  28. Y. F. Shih, M. E. Fitzgerald, T. T. Norton, et al., “Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia,” Current Eye Research, vol. 12, no. 3, pp. 219–227, 1993. View at Scopus
  29. T. Tokoro, “Diffuse chorioretinal atrophy,” in Atlas of Posterior Fundus Changes in Pathological Myopia, pp. 7–14, Springer, Tokyo, Japan, 1998.
  30. T. Wakabayashi and Y. Ikuno, “Choroidal filling delay in choroidal neovascularisation due to pathological myopia,” British Journal of Ophthalmology, vol. 94, no. 5, pp. 611–615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Noma, H. Funatsu, M. Yamasaki, et al., “Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion,” Eye, vol. 22, no. 1, pp. 42–48, 2008. View at Publisher · View at Google Scholar · View at Scopus