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Journal of Ophthalmology
Volume 2013 (2013), Article ID 262467, 15 pages
http://dx.doi.org/10.1155/2013/262467
Review Article

Using the Electroretinogram to Understand How Intraocular Pressure Elevation Affects the Rat Retina

1Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC 3010, Australia
2Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, OR 97232, USA

Received 11 September 2012; Accepted 24 October 2012

Academic Editor: Shigeki Machida

Copyright © 2013 Bang V. Bui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Intraocular pressure (IOP) elevation is a key risk factor for glaucoma. Our understanding of the effect that IOP elevation has on the eye has been greatly enhanced by the application of the electroretinogram (ERG). In this paper, we describe how the ERG in the rodent eye is affected by changes in IOP magnitude, duration, and number of spikes. We consider how the variables of blood pressure and age can modify the effect of IOP elevation on the ERG. Finally, we contrast the effects that acute and chronic IOP elevation can have on the rodent ERG.