Systems Biology Profiling of AMD on the Basis of Gene Expression

Table 3

Affected retinal signaling pathways at different locations of cladogram in Figure 1. Sample identification follows http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29801.

First node; Shared by all retinal specimens	RetMD1-106; (Sample GSM738713); Lower part of the cladogram	Specimen: RetDRY98; (Sample GSM738705); Middle part of the cladogram	Specimen: RetDRY70; (Sample GSM738677); Upper part of the cladogram
(1) Apoptosis; (2) Cell cycle; (3) Cytoskeleton; (4) Differentiation; (5) Growth; (6) Insulin metabolism	(1) Apoptosis; (2) Cell cycle; (3) Development; (4) Growth; (5) Neurotransmission; (6) Transcription activation; (7) Tumor suppression	(1) Cytokine receptor degradation signaling; (2) Cytosolic calcium ion concentration elevation (through IP3 receptor) (GPCR signaling (G alpha q)); (3) EGFR1; (4) ERK cascade GPCR signaling (G alpha s, PKA, and ERK); (5) Protein binding; (6) Proteolysis	(1) Amyloid metabolism; (2) Apoptosis; (3) Cell cycle; (4) Cytoskeleton; (5) Immunoregulation; (6) Inflammation; (7) Lipid metabolism; (8) Retinoid metabolism; (9) Ribosomal proteins; (10) Telomere metabolism