Methotrexate for the Treatment of Thyroid Eye Disease

Table 3

Ocular motility, exophthalmos, and MRD results before and after 3, 6, and 12 months of methotrexate therapy.

Parameters	Baseline	At 3 months	At 6 months	At 12 months
Ocular motility; Patients with gaze restriction (no. and %)	15 (42%)	11 (30%)	5 (14%)	5 (14%)
𝑃 value; 𝑃 (versus baseline)		=0.03	<0.001	<0.001
Mean exophthalmometry (mm) ± SD	24±3	24±2.5	24±2	24±3.5
𝑃 value; 𝑃 (versus baseline)		=1	=0.1	=0.03
Mean MRD (mm) ± SD	6±1.5	6±1	5±1.5	5±1.5
𝑃 value; 𝑃 (versus baseline)		=1	=0.06	=0.06

Bold data are referred to statistically significant 𝑃 values.