RHO Mutations (p.W126L and p.A346P) in Two Japanese Families with Autosomal Dominant Retinitis Pigmentosa

Figure 4

Projected view from the cytoplasmic side of the backbone before and after the 1 ns molecular dynamics (MD) simulations. The side chain of the position 126 in each model is shown by the bold sticks in the corresponding colors. (a) Dark-adapted like models. Blue: wild-type after 1 ns MD; green: wild-type before MD. (b) Dark-adapted like models. Red: W126L after 1 ns MD; green: W126L before MD. (c) Light-adapted like models. Blue: wild-type after 1 ns MD; green: wild-type before MD. (d) Light-adapted like models. Red: W126L after 1 ns MD; green: W126L before MD.

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