Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution

Table 1

Effect of cyclodextrins (CD) on corneal lutein accumulation in combination with NLC*.

Vehicles	Accumulation rate (μg/g/hr)	Partition coefficient (10^−3)	Enhance; ratio
NLC	10.6 ± 0.4	21.25 ± 0.8	1
NLC + αCD	12.1 ± 3	24.20 ± 6.2	1.14
NLC + βCD	16.2 ± 9	32.40 ± 1.5	1.52
NLC + HEβCD	16.2 ± 3.5	32.45 ± 7.1	1.53
NLC + HPβCD	19.8 ± 0.2	39.80 ± 0.6	1.80

∗The CD and lutein content in the tested vehicles is 0.5% and 2000 μg/g, respectively.