Correlation of Optic Nerve Microcirculation with Papillomacular Bundle Structure in Treatment Naive Normal Tension Glaucoma
Table 1
Characteristics of patients.
Characteristics
NTG
Normal people
value
Number, mean ± SD
Number, mean ± SD
Number
40
20
—
Gender
Male
19 (19 eyes)
10 (10 eyes)
0.81*
Female
21 (21 eyes)
10 (10 eyes)
Laterality
Right
21
9
0.81*
Left
19
11
Age (years)
63.3 ± 9.6
59.7 ± 9.9
0.16**
BCVA ()
0.10 ± 0.2
−0.10 ± 0.08
<0.01**
IOP (mmHg)
14.6 ± 3.2
16.2 ± 3.3
0.18**
Refractive error (diopter)
−2.94 ± 2.3
−2.04 ± 2.2
0.17**
HFA 30–2 mean deviation (MD; dB)
−11.9 ± 8.4
0.17 ± 1.3
<0.01**
Macular area
RNFLT (m)
19.1 ± 9.1
34.5 ± 4.0
<0.01**
GCCT (m)
75.3 ± 14.7
101.6 ± 7.0
<0.01**
Central papillomacular bundle
RNFLT (m)
Upper
36.4 ± 21.2
66.9 ± 15.6
<0.01**
Middle
30.3 ± 13.9
42.2 ± 7.7
<0.01**
Lower
29.1 ± 21.0
70.9 ± 18.1
<0.01**
GCCT (m)
Upper
81.5 ± 25.1
117.2 ± 14.2
<0.01**
Middle
90.7 ± 24.9
114.5 ± 9.5
<0.01**
Lower
75.3 ± 21.4
120.7 ± 17.7
<0.01**
Circumpapillary RNFLT (m)
Total
81.2 ± 12.2
107.3 ± 10.6
<0.01**
Temporal
71.1 ± 17.5
84.9 ± 11.5
<0.01**
Superior
98.3 ± 19.2
126.6 ± 16.3
<0.01**
Nasal
75.1 ± 16.3
86.1 ± 15.9
<0.01**
Inferior
80.4 ± 20.6
131.5 ± 17.0
<0.01**
LSFG MBR (AU)
MA
Temporal
8.6 ± 2.6
11.8 ± 2.1
—
Superior
20.4 ± 6.1
28.3 ± 5.6
—
Nasal
21.5 ± 6.3
29.9 ± 6.4
—
Inferior
17.5 ± 5.0
26.7 ± 5.3
—
MT
Temporal
7.8 ± 2.0
10.1 ± 1.6
—
Superior
10.8 ± 2.7
12.6 ± 2.0
—
Nasal
11.9 ± 2.5
13.5 ± 1.6
—
Inferior
10.0 ± 2.4
12.9 ± 1.8
—
MV
Temporal
27.2 ± 10.1
36.9 ± 12.7
—
Superior
37.9 ± 9.0
48.0 ± 5.2
—
Nasal
36.3 ± 8.9
48.4 ± 7.6
—
Inferior
35.1 ± 7.7
44.7 ± 5.1
—
Temporal/nasal MT
0.66 ± 0.1
0.75 ± 0.1
<0.01**
Systolic blood pressure (SBP) (mmHg)
127.1 ± 20.4
133.7 ± 21.7
0.26**
Diastolic blood pressure (DBP) (mmHg)
77.8 ± 14.5
82.9 ± 14.1
0.07**
Heart rate (HR) (bpm)
73.2 ± 11.1
76.9 ± 9.9
0.16**
NTG: normal tension glaucoma, BCVA: best-corrected visual acuity, : logarithm of the minimal angle resolution, IOP: intraocular pressure, HFA: Humphrey field analyzer, RNFLT: retinal nerve fiber layer thickness, GCCT: ganglion cell complex thickness, MBR: mean blur rate, AU: arbitrary unit, MA: mean MBR in all areas, MT: mean MBR in the tissue area, and MV: mean MBR in the vessel area. Fisher’s exact test, **Mann-Whitney test.
