High-Resolution In Vivo Imaging of Regimes of Laser Damage to the Primate Retina
Figure 9
Fundus and OCT B-scans of 413 nm exposures in the retina of one subject. (a) Lesions 11–13 (474 J/cm2) were not positively identified as MVLs in color fundus photos at the 1-hour observation point. (b) At the 24-hour observation point, all three exposure sites were positively identified as a MVL. OCT B-scans collected within minutes of the initial exposure (c) reveal a hyperreflective “clumping” in the photoreceptor inner segment layer. The RPE layer shows a modest increase in reflectance with a “granular” appearance. (d) The damage surrounding the RPE and photoreceptors becomes more distinguishable 24 hours later. A wispy “threading” at the boundary of the inner nuclear layer (INL) and outer plexiform layer (OPL) for lesions 11 and 12 becomes observable. An increased reflectance of the inner retinal layers directly above the lesion site suggests an edematous reaction. Nine days later, (e) the damage appears more homogenous and extends from its base at the RPE into the connecting cilia of the photoreceptors.
