Evaluation of Epithelial Integrity with Various Transepithelial Corneal Cross-Linking Protocols for Treatment of Keratoconus

Table 1

Overview of the different riboflavin formulations, formulation compositions, and the UVA light source, and if iontophoresis was used in this study.

Riboflavin formulation	Formulation composition	UVA delivery device	Iontophoresis
Ricrolin TE (Sooft, Italy)	0.1% riboflavin-5-phosphate,; 15% dextran T500, sodium edetate, trometamol, and NaCl	UV-X 1000, IROC Innocross, Switzerland	N/A
Medio-Cross TE (Peschke Meditrade GmbH, Germany)	0.25% riboflavin-5-phosphate hydroxypropyl methylcellulose, benzalkonium chloride, NaCl	UV-X 1000, IROC Innocross, Switzerland	N/A
ParaCel (Avedro Inc., USA)	0.25% riboflavin-5-phosphate, hydroxypropyl methylcellulose, sodium edetate, trometamol, benzalkonium chloride, NaCL	KXL, Avedro Inc., USA	N/A
Ricrolin+ (Sooft, Italy)	0.1% riboflavin-5-phosphate, sodium edetate, trometamol, sodium dihydrogen phosphate dihydrate, and sodium phosphate dibasic dehydrate	KXL, Avedro, Inc., USA	I-ON CXL generator (Sooft, Italy)
VibeX Xtra (Avedro Inc., USA)	0.25% riboflavin-5-phosphate and NaCl	KXL, Avedro, Inc., USA	N/A