Correlations between ERG, OCT, and Anatomical Findings in the rd10 Mouse
Figure 1
Electroretinogram recordings in wild type and rd10 mice. (a) Left: mice were fixed in front of a Ganzfeld stimulator in a standardized position. Right: goldring electrodes were used on both eyes as active electrodes. A goldring electrode in the mouth served as reference and a subcutaneous needle electrode in the lumbar region as ground electrode. (b) The first graph serves as example for an ERG recording with designated a-wave and b-wave. In the following examples, ERGs of the left eye of wild type (second graph) and rd10 mice (third graph) at different ages (2, 3, 5, and 9 weeks) are illustrated. While in wild type mice, the amplitudes of a- and b-waves increased with age up to 12 weeks, in rd10 mice, an ERG was only recordable until the age of 3 weeks. (c) Amplitudes of the ERG’s a-wave (left panel) and b-wave (right panel) in wild type mice (black bars) and rd10 mice (grey bars) are plotted against the stimulus intensity (first row: 0.3 cds/m2, second row: 1 cds/m2 and third row: 3 cds/m2) and to age given on the abscissa. Vertical bars indicate the mean values ± standard deviation ( per age group).
