Effects of Zeaxanthin on Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model

Figure 3

Microscopic photographs of mouse eyes inoculated with human uveal melanoma cells with or without zeaxanthin treatment (original magnification 100). Eyes were stained with hematoxylin-eosin in frozen section and observed under oil lens. Tumor cells in the eye not treated with zeaxanthin are mostly epithelioid in morphology with few spindle cells. Large nuclei and prominent nucleoli were observed in the tumor cells (a). Mitoses are common (arrow M). In eyes treated with high dosage of zeaxanthin, necrotic (arrow N) or apoptotic tumor cells (arrow A) can be observed. No mitotic figures are present (b).

(a)

(b)