Multivariate Analysis of the Ocular Response Analyzer’s Corneal Deformation Response Curve for Early Keratoconus Detection

Table 2

Biomechanical descriptors in control and keratoconic eyes. Corneal waveform descriptors of control (group 1) and subclinical keratoconus (group 2) eyes. Data is expressed as mean ± standard deviation. AROC = area under the curve; CI = confidence interval.

Descriptor	Group 1 (mean ± SD)	Group 2 (mean ± SD)		AROC (95% CI)
CH	9.62 ± 1.46	8.50 ± 1.36	<0.001	0.71 (0.63–0.79)
CRF	9.35 ± 1.46	7.37 ± 1.37	<0.001	0.84 (0.78–0.9)
ccCH	−0.17 ± 1.30	−1.04 ± 1.19	<0.001	0.70 (0.62–0.78)
ccCRF	−0.20 ± 1.22	−1.87 ± 1.13	<0.001	0.85 (0.79–0.91)
CH-CRF	0.27 ± 0.92	1.13 ± 0.78	<0.001	0.77 (0.84–0.7)
timein	7.74 ± 0.39	7.19 ± 0.37	<0.001	0.85 (0.79–0.91)
timeout	18.48 ± 0.23	18.35 ± 0.24	0.001	0.65 (0.57–0.74)
deltatime	10.74 ± 0.44	11.16 ± 0.45	<0.001	0.76 (0.69–0.84)
aindex	7.82 ± 1.14	7.27 ± 1.41	0.008	0.62 (0.53–0.71)
bindex	8.16 ± 1.46	6.98 ± 1.87	<0.001	0.68 (0.6–0.77)
p1area	3887.14 ± 867.29	3360.05 ± 1279.24	0.003	0.68 (0.59–0.76)
p2area	2237.06 ± 626.53	1787.33 ± 609.35	<0.001	0.7 (0.62–0.78)
aspect1	20.91 ± 4.59	18.39 ± 5.35	0.002	0.64 (0.56–0.73)
aspect2	18.57 ± 7.34	13.73 ± 7.29	<0.001	0.69 (0.61–0.78)
uslope1	79.80 ± 22.53	69.10 ± 22.13	0.003	0.64 (0.55–0.73)
uslope2	87.20 ± 32.35	66.82 ± 34.67	<0.001	0.69 (0.6–0.77)
dslope1	29.72 ± 6.93	26.63 ± 8.57	0.014	0.62 (0.53–0.71)
dslope2	24.38 ± 10.35	17.94 ± 9.71	<0.001	0.68 (0.6–0.77)
w1	22.30 ± 2.39	22.57 ± 2.84	0.513	0.54 (0.45–0.63)
w2	20.35 ± 4.81	22.51 ± 5.87	0.013	0.61 (0.52–0.70)
h1	440.97 ± 84.47	386.16 ± 107.79	0.001	0.66 (0.57–0.75)
h2	310.47 ± 83.16	235.14 ± 87.32	<0.001	0.74 (0.66–0.82)
dive1	367.21 ± 96.01	318.10 ± 99.11	0.002	0.65 (0.56–0.74)
dive2	234.06 ± 70.57	173.78 ± 71.64	<0.001	0.74 (0.66–0.81)
path1	24.64 ± 3.66	26.02 ± 4.50	0.038	0.6 (0.69–0.51)
path2	27.18 ± 4.86	27.44 ± 4.61	0.733	0.52 (0.43–0.61)
mslew1	141.48 ± 31.79	128.10 ± 32.48	0.010	0.61 (0.53–0.7)
mslew2	138.38 ± 43.12	106.51 ± 41.92	<0.001	0.7 (0.62–0.78)
slew1	85.83 ± 23.30	77.59 ± 22.41	0.024	0.62 (0.53–0.71)
slew2	89.07 ± 31.61	70.48 ± 33.82	<0.001	0.68 (0.59–0.76)
aplhf	1.63 ± 0.33	1.73 ± 0.38	0.105	0.57 (0.65–0.48)
p1area1	1612.69 ± 416.66	1381.53 ± 625.19	0.008	0.67 (0.59–0.76)
p2area1	937.39 ± 278.33	736.97 ± 290.89	<0.001	0.71 (0.62–0.79)
aspect11	30.77 ± 8.38	28.03 ± 9.16	0.052	0.6 (0.51–0.69)
aspect21	27.31 ± 10.44	20.31 ± 10.37	<0.001	0.7 (0.62–0.78)
uslope11	78.81 ± 22.38	69.05 ± 21.91	0.006	0.64 (0.55–0.72)
uslope21	71.29 ± 26.17	55.64 ± 28.37	<0.001	0.68 (0.6–0.76)
dslope11	51.57 ± 16.01	48.63 ± 17.63	0.276	0.55 (0.46–0.64)
dslope21	42.30 ± 17.25	30.58 ± 16.47	<0.001	0.70 (0.62–0.78)
w11	10.98 ± 2.06	10.71 ± 1.90	0.400	0.53 (0.44–0.62)
w21	9.31 ± 2.33	10.26 ± 2.88	0.024	0.6 (0.51–0.69)
h11	293.98 ± 56.31	257.44 ± 71.86	0.001	0.66 (0.57–0.75)
h21	206.98 ± 55.44	156.76 ± 58.22	<0.001	0.74 (0.66–0.82)
path11	35.76 ± 5.52	37.56 ± 7.06	0.078	0.59 (0.68–0.5)
path21	37.49 ± 6.59	37.87 ± 6.75	0.715	0.51 (0.6–0.42)