Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes

Figure 2

Abnormal changes in the PERG parameters of diabetic mice (db/db) were found at different week periods compared with nondiabetic mice (db/+). The P1 amplitudes and latency recorded from diabetic and control mice (, resp.) were compared at each endpoint. db/db mice had an insignificant lower P1 amplitude than littermates at each point and showed significant amplitude reduction for 20 weeks (a). Significant delay of P1 latency was observed in db/db mice at 24 and 28 weeks (b). Data are expressed as mean ± SE. ; .

(a)

(b)