Retinal Neurodegeneration in db/db Mice at the Early Period of Diabetes
Table 1
Retinal thickness from OCT in diabetic and nondiabetic mice at 28 weeks.
Thickness (μm)
Db/db mice
Db/+ mice
95% confidence interval
value#
Global retina
221.7 ± 2.27
237.48 ± 1.98
−22.33, −9.24
0.0002**
Superior
214.36 ± 2.26
230.21 ± 2.68
−23.49, −8.23
0.0007**
Nasal
224.21 ± 3.09
238.93 ± 1.28
−22, −7.43
0.0009**
Inferior
230.86 ± 4.15
245.43 ± 2.25
−24.85, −4.29
0.0094**
Temporal
217.36 ± 1.82
235.36 ± 2.6
−24.91, −11.09
0.0001**
central
179.57 ± 5.92
196.29 ± 10.16
−42.32, 8.9
0.1805
Superior-inner
204.86 ± 3.32
223.71 ± 4.21
−30.53, −7.18
0.0042**
Superior-outer
223.86 ± 3.59
236.71 ± 1.6
−21.42, −4.3
0.0067**
Nasal-inner
218.29 ± 3.3
234.86 ± 2.35
−25.4, −7.74
0.0015**
Nasal-outer
230.14 ± 3.15
243 ± 1.63
—
0.0103*
Inferior-inner
228.43 ± 3.48
244 ± 2.69
−25.16, −5.98
0.0041**
Inferior-outer
233.29 ± 6.18
246.86 ± 3.03
−28.59, 1.43
0.0723
Temporal-inner
205.43 ± 2.38
227 ± 3.69
−31.14, −12
0.0004**
Temporal-outer
229.29 ± 2.96
243.71 ± 1.94
−22.13, −6.73
0.0015**
Retinal thicknesses in db/db mice and littermates were shown as mean ± SE, in each group, and one eye was selected at random in each mouse and only that eye was included in the analysis; unpaired student’s -test was used to analyze the thickness data. Wilcoxon rank sum test was used in the analysis of nasal-outer thickness due to the sample skewed distribution. The central fovea thickness was not included in the whole thickness of global retina. * < 0.05. ** < 0.01.
