Safety and Biocompatibility of a New High-Density Polyethylene-Based Spherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits

Figure 4

Histological findings in hematoxylin & eosin (HE) stained sections at 180 days after orbital implantation. Loose granulation tissue (a) with an associated foreign body giant cell reaction ((b), (c)) was commonly observed at 90 and 180 days after MEDPOR, OCULFIT I, and OCULFIT II implantation. Metaplastic changes (d), focal intraocular hemorrhage (e), and focal osseous metaplasia (f) were occasionally observed at 180 days after MEDPOR, OCULFIT I, and OCULFIT II implantation, respectively. Scale bars: 50 µm ((a), (d), MEDPOR; (e), OCULFIT I; (f), OCULFIT II) and 20 µm ((b), OCULFIT I; (c), OCULFIT II).

(a)

(b)

(c)

(d)

(e)

(f)