iTRAQ-Based Proteomic Analysis of Visual Cycle-Associated Proteins in RPE of rd12 Mice before and after RPE65 Gene Delivery

Figure 1

ERG records of untreated rd12, treated rd12, and normal control C57BL/6J eyes. (a) Scotopic ERG of the 3 groups at P42; (b) photopic ERG at P42. (c) and (d) represent statistical comparison of a-wave and b-wave amplitudes among the different groups at P42 under scotopic and photopic conditions. The untreated rd12 eyes showed extremely low a-wave and b-wave response in both scotopic and photopic ERGs. The treated rd12 eyes had great improvement in both a-wave and b-wave amplitudes with normal peak time, close to the wide-type control levels. NS: no significance. ; .

(a)

(b)

(c)

(d)