Journal of Ophthalmology

Review Article

Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis

Table 5

Outcome measures data of the included studies.


Study	Results of PSV (cm/s) (NTG/control)	Results of EDV (cm/s) (NTG/control)	Results of RI (NTG/control)

[29]	OA: 33.6 ± 11.2/40.1 ± 16.9	OA: 6.79 ± 3.32/7.35 ± 4.36	OA: 0.80 ± 0.07/0.82 ± 0.07
	CRA: 10.32 ± 3.58/12.0 ± 4.38	CRA: 2.87 ± 1.08/3.10 ± 1.12	CRA: 0.71 ± 0.08/0.73 ± 0.07
	NPCA: 8.58 ± 2.69/11.08 ± 3.76	NPCA: 2.92 ± 0.99/3.53 ± 1.53	NPCA: 0.65 ± 0.07/0.68 ± 0.08
	TPCA: 9.12 ± 2.81/11.0 ± 3.87	TPCA: 3.06 ± 1.09/3.45 ± 1.36	TPCA: 0.66 ± 0.08/0.68 ± 0.08

[43]	OA: 35.3 ± 10.7/41.7 ± 18.8	OA: 7.5 ± 3.5/8.3 ± 5.3	OA: 0.79 ± 0.07/0.81 ± 0.07
	CRA: 10.6 ± 4.0/12.1 ± 4.0	CRA: 2.8 ± 0.98/3.2 ± 1.2	CRA: 0.71 ± 0.08/0.73 ± 0.07
	NPCA: 8.2 ± 2.6/11.6 ± 4	NPCA: 2.8 ± 0.9/3.6 ± 1.6	NPCA: 0.65 ± 0.07/0.68 ± 0.08
	TPCA: 9.2 ± 3.1/11.5 ± 3.9	TPCA: 3.1 ± 1.2/3.6 ± 1.5	TPCA: 0.66 ± 0.07/0.68 ± 0.08

[44]	OA: 31.6 ± 10/37.7 ± 17	OA: 5.81 ± 3.7/6.85 ± 3.9	OA: 0.82 ± 0.1/0.82 ± 0.1
	CRA: 10.7 ± 3.4/11.9 ± 4.3	CRA: 2.96 ± 1.1/3.20 ± 1.2	CRA: 0.71 ± 0.1/0.72 ± 0.1
	NPCA: 9.51 ± 2.8/9.29 ± 2.7	NPCA: 3.2 ± 1.0/3.13 ± 1.1	NPCA: 0.66 ± 0.1/0.66 ± 0.1
	TPCA: 9.20 ± 2.7/8.97 ± 2.4	TPCA: 3.06 ± 0.9/3.08 ± 0.9	TPCA: 0.66 ± 0.1/0.65 ± 0.1

[45]	OA: 32.9 ± 10/39.7 ± 17	OA: 6.03 ± 3.8/7.96 ± 4.6	OA: 0.82 ± 0.1/0.80 ± 0.1
	CRA: 10.6 ± 3.5/12.9 ± 4.4	CRA: 2.88 ± 0.9/3.55 ± 1.3	CRA: 0.71 ± 0.1/0.72 ± 0.1
	NPCA: 9.52 ± 3.0/10.8 ± 4.1	NPCA: 3.33 ± 1.2/3.81 ± 1.7	NPCA: 0.64 ± 0.1/0.65 ± 0.1
	TPCA: 9.54 ± 3.3/11.1 ± 3.7	TPCA: 3.22 ± 1.2/3.80 ± 1.4	TPCA: 0.66 ± 0.1/0.65 ± 0.1

[46]	OA: NA	OA: NA	OA: 0.72 ± 0.07/0.69 ± 0.06
	CRA: NA	CRA: NA	CRA: 0.60 ± 0.06/0.53 ± 0.07
	NPCA: NA	NPCA: NA	NPCA: 0.61 ± 0.07/0.53 ± 0.06
	TPCA: NA	TPCA: NA	TPCA: 0.61 ± 0.08/0.54 ± 0.06

[47]	OA: 30.4 ± 7.6/30.1 ± 9.9	OA: 6.6 ± 2.9/8.4 ± 2.9	OA: 0.77 ± 0.08/0.72 ± 0.05
	CRA: 12.8 ± 9.1/13.4 ± 6.3	CRA: 1.9 ± 1.9/2.6 ± 1.6	CRA: 0.87 ± 0.09/0.80 ± 0.08
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[48]	OA: 31.5 ± 8.1/30.8 ± 10.6	OA: 7.1 ± 2.9/8.3 ± 3.1	OA: 0.77 ± 0.08/0.73 ± 0.05
	CRA: 12.4 ± 7.9/13.0 ± 6.2	CRA: 1.7 ± 1.8/3.0 ± 1.6	CRA: 0.86 ± 0.09/0.77 ± 0.09
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[49]	OA: 32.961 ± 11.793/36.646 ± 25.604	OA: NA	OA: 0.717 ± 0.074/0.789 ± 0.070
	CRA: NA	CRA: NA	CRA: NA
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[50]	OA: 28.9 ± 10/30.9 ± 8.4	OA: 4.3 ± 1.5/5 ± 2.5	OA: 0.84 ± 0.07/0.84 ± 0.05
	CRA: 9.3 ± 2.8/9.6 ± 3.5	CRA: 2.09 ± 1.2/2.07 ± 0.78	CRA: 0.78 ± 0.1/0.77 ± 0.07
	NPCA: 7.4 ± 3.6/7.7 ± 2.9	NPCA: 2.1 ± 1.7/1.8 ± 0.9	NPCA: 0.72 ± 0.11/0.77 ± 0.07
	TPCA: 7.5 ± 2.4/8.4 ± 2.6	TPCA: 2.1 ± 0.74/2.1 ± 0.98	TPCA: 0.71 ± 0.07/0.75 ± 0.08

[51]	OA: 37.320 ± 1.729	OA: NA	OA: 0.708 ± 0.008
	CRA: NA	CRA: NA	CRA: NA
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[52]	OA: 28.4 ± 10.8/35.8 ± 8.4	OA: 7.71 ± 3.73/8.03 ± 2.40	OA: 0.725 ± 0.084/0.776 ± 0.035
	CRA: 9.89 ± 3.31/11.3 ± 3.1	CRA: 2.88 ± 1.17/4.18 ± 1.06	CRA: 0.711 ± 0.046/0.627 ± 0.038
	NPCA: 9.03 ± 3.23/8.13 ± 1.85	NPCA: 3.18 ± 1.40/3.43 ± 1.10	NPCA: 0.651 ± 0.061/0.584 ± 0.059
	TPCA: 8.76 ± 2.53/10.2 ± 2.8	TPCA: 2.95 ± 0.93/3.95 ± 1.27	TPCA: 0.662 ± 0.055/0.614 ± 0.060

[53]	OA: 35.50 ± 9.84/31.40 ± 13.42	OA: 7.80 ± 3.58/7.60 ± 5.81	OA: 0.77 ± 0.09/0.78 ± 0.09
	CRA: 9.80 ± 3.13/11.10 ± 2.24	CRA: 2.7 ± 1.34/3.30 ± 1.79	CRA: 0.73 ± 0.09/0.70 ± 0.09
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[54]	OA: 25.43 ± 5.34/32.90 ± 6.17	OA: 5.87 ± 1.17/11.41 ± 2.30	OA: 0.76 ± 0.03/0.64 ± 0.03
	CRA: 11.41 ± 1.96/12.14 ± 1.80	CRA: 3.72 ± 0.77/5.67 ± 1.11	CRA: 0.66 ± 0.07/0.52 ± 0.08
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[55]	OA: 34.9 ± 9.3/35.9 ± 9.1	OA: 4.8 ± 2.3/9.9 ± 5.2	OA: 0.87 ± 0.06/0.73 ± 0.08
	CRA: 8.5 ± 1.8/8.7 ± 2.2	CRA: 1.2 ± 1.1/2.5 ± 1.1	CRA: 0.86 ± 0.12/0.72 ± 0.08
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[56]	OA: 30.16 ± 10.21	OA: 7.97 ± 2.84	OA: 0.78 ± 0.07
	CRA: 30.75 ± 7.64	CRA: 6.85 ± 3.35	CRA: 0.73 ± 0.05
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[57]	OA: 35.87 ± 9.71/38.90 ± 5.57	OA: 7.68 ± 2.65/9.15 ± 2.23	OA: 0.78 ± 0.07/0.75 ± 0.07
	CRA: 9.24 ± 1.77/11.10 ± 1.11	CRA: 2.29 ± 0.88/3.23 ± 0.78	CRA: 0.75 ± 0.07/0.70 ± 0.06
	NPCA: 10.46 ± 2.65/11.27 ± 1.11	NPCA: 2.81 ± 0.88/3.57 ± 0.89	NPCA: 0.71 ± 0.08/0.68 ± 0.06
	TPCA: 9.77 ± 1.77/11.12 ± 1.11	TPCA: 2.91 ± 0.88/3.57 ± 0.89	TPCA: 0.70 ± 0.08/0.68 ± 0.06

[58]	OA: 29.2 ± 9.4/36.0 ± 8.3	OA: 8.1 ± 3.3/8.1 ± 3.7	OA: 0.73 ± 0.06/0.78 ± 0.07
	CRA: 7.2 ± 1.6/9.8 ± 2.2	CRA: 1.8 ± 0.9/3.2 ± 0.7	CRA: 0.75 ± 0.10/0.67 ± 0.07
	NPCA: 6.8 ± 1.2/8.5 ± 1.7	NPCA: 2.1 ± 0.8/3.5 ± 0.6	NPCA: 0.70 ± 0.10/0.59 ± 0.05
	TPCA: 7.3 ± 1.3/8.4 ± 1.9	TPCA: 2.2 ± 1.0/3.5 ± 0.8	TPCA: 0.70 ± 0.12/0.58 ± 0.06

[30]	OA: 30.8 ± 8.8/32.8 ± 9.1	OA: 7.8 ± 3.2/7.4 ± 3.5	OA: 0.75 ± 0.07/0.78 ± 0.07
	CRA: 7.6 ± 1.8/9.3 ± 1.9	CRA: 2.0 ± 0.9/2.9 ± 0.9	CRA: 0.74 ± 0.09/0.69 ± 0.06
	NPCA: 6.9 ± 1.5/7.6 ± 1.8	NPCA: 2.2 ± 0.9/2.7 ± 0.7	NPCA: 0.69 ± 0.09/0.63 ± 0.07
	TPCA: 7.3 ± 2.3/7.5 ± 1.7	TPCA: 2.3 ± 1.0/2.8 ± 0.7	TPCA: 0.69 ± 0.1/0.62 ± 0.07

[59]	OA: NA	OA: NA	OA: NA
	CRA: 12.0 ± 2.9/14.5 ± 4.7	CRA: 3.2 ± 1.3/4.5 ± 1.5	CRA: 0.74 ± 0.08/0.69 ± 0.08
	NPCA: 9.0 ± 1.9/9.6 ± 1.9	NPCA: 2.8 ± 1.0/3.4 ± 1.0	NPCA: 0.70 ± 0.09/0.66 ± 0.09
	TPCA: 9.0 ± 2.2/10.0 ± 2.1	TPCA: 2.9 ± 0.85/3.8 ± 1.3	TPCA: 0.68 ± 0.09/0.62 ± 0.09

[60]	OA: 35.35 ± 7.78/43.86 ± 7.81	OA: 8.96 ± 2.66/11.92 ± 2.60	OA: NA
	CRA: NA	CRA: NA	CRA: NA
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

[61]	OA: 36.8 ± 14.1/45.8 ± 16.0	OA: 7.4 ± 3.1/10.4 ± 6.1	OA: 0.79 ± 0.08/0.78 ± 0.08
	CRA: 9.1 ± 3.4/14.0 ± 3.5	CRA: 2.9 ± 0.9/3.7 ± 1.2	CRA: 0.67 ± 0.08/0.73 ± 0.08
	NPCA: 10.1 ± 3.5/12.8 ± 4.5	NPCA: 3.4 ± 1.3/4.3 ± 2.0	NPCA: 0.66 ± 0.07/0.67 ± 0.07
	TPCA: 10.1 ± 4.0/12.8 ± 3.9	TPCA: 3.4 ± 1.5/4.3 ± 1.7	TPCA: 0.68 ± 0.07/0.66 ± 0.08

[62]	OA: 30.25 ± 10.5/36.63 ± 14.5	OA: 5.24 ± 2.3/6.55 ± 4.1	OA: 0.82 ± 0.1/0.82 ± 0.1
	CRA: 10.31 ± 3.1/11.16 ± 4.6	CRA: 2.92 ± 1.0/3.00 ± 1.3	CRA: 0.71 ± 0.1/0.73 ± 0.1
	NPCA: 9.22 ± 2.7/10.29 ± 3.3	NPCA: 3.16 ± 1.0/3.28 ± 1.3	NPCA: 0.65 ± 0.1/0.67 ± 0.1
	TPCA: 9.07 ± 2.3/10.1 ± 3.5	TPCA: 3.00 ± 0.8/3.31 ± 1.4	TPCA: 0.66 ± 0.1/0.66 ± 0.1

[28]	OA: 31.50 ± 8.40/39.55 ± 7.24	OA: 8.37 ± 2.93/12.64 ± 4.36	OA: 0.73 ± 0.06/0.69 ± 0.07
	CRA: 10.04 ± 3.09/12.36 ± 2.84	CRA: 3.49 ± 0.99/4.77 ± 1.77	CRA: 0.66 ± 0.07/0.61 ± 0.07
	NPCA: NA	NPCA: NA	NPCA: NA
	TPCA: NA	TPCA: NA	TPCA: NA

NTG = normal tension glaucoma; IOP = intraocular pressure; PSV = peak systolic velocity; EDV = end diastolic velocity; RI = resistive index; OA = ophthalmic artery; CRA = central retinal artery; NPCA = nasal short posterior ciliary artery; TPCA = temporal short posterior ciliary artery; NA = not available.