High MMP-9 Expression May Contribute to Retroprosthetic Membrane Formation after KPro Implantation in Rabbit Corneal Alkali Burn Model
Table 1
Dynamic expressions of MMP-9 and TIMP-1 in aqueous humor of alkali-burned rabbit cornea following Boston Type 1 keratoprosthesis (KPro) implantation.
Time
MMP-9 (ng/mL)
TIMP-1 (ng/mL)
Group III
Group II
Group I
Group III
Group II
Group I
Preoperation
22.85 ± 4.20
22.52 ± 4.03
22.39 ± 3.36
29.42 ± 1.05
29.44 ± 1.08
29.37 ± 1.01
Day 7
33.48 ± 7.29
43.54 ± 4.39#
22.47 ± 4.13
27.44 ± 1.16#
26.57 ± 1.94#
29.46 ± 1.14
Day 14
40.55 ± 8.43
75.48 ± 5.20#
22.41 ± 3.56
24.51 ± 1.98
21.45 ± 3.59#
29.51 ± 1.31
Day 28
56.42 ± 3.56#
52.39 ± 6.83#
22.40 ± 4.15
21.44 ± 3.57#
23.50 ± 2.77#
29.52 ± 1.13
Day 60
69.55 ± 3.52
45.44 ± 6.02#
22.39 ± 4.16
19.42 ± 1.96
25.41 ± 1.96#
29.54 ± 1.30
Day 90
83.42 ± 7.63
38.53 ± 3.54#
22.36 ± 3.55
14.49 ± 4.36
28.46 ± 6.84
29.58 ± 1.37
Group III: corneal alkali-burned rabbits implanted with Boston Type 1 keratoprosthesis (KPro); group II: corneal alkali-burned rabbits with penetrating keratoplasty; group I: corneal alkali-burned rabbits without keratoplasty. versus group II, # versus group I.
