Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation

Table 3

Risk of pterygium formation based on gene promoter methylation.

Gene	Methylation status	Pterygium tissues	Normal tissues	OR	95% CI
		(%)	(%)
Exact method
LATS1	U (ref)	4 (5.71)	16 (22.86)	4.9	1.44 to 21.06	0.003
	M	66 (94.28)	54 (77.14)
LATS2	U (ref)	2 (2.85)	12 (17.14)	7.1	1.47 to 67.42	0.004
	M	69 (98/57)	58 (82.86)
Cornfield method
LATS1	U (ref)	4 (5.71)	16 (22.86)	4.9	1.60 to 14.76	0.003
	M	66 (94.28)	54 (77.14)
LATS2	U (ref)	2 (2.85)	12 (17.14)	7.1	1.70 to NC	0.004
	M	69 (98/57)	58 (82.86)
Woolf method
LATS1	U (ref)	4 (5.71)	16 (22.86)	4.9	1.54 to 15.48	0.003
	M	66 (94.28)	54 (77.14)
LATS2	U (ref)	2 (2.85)	12 (17.14)	7.1	1.53 to 33.19	0.004
	M	69 (98/57)	58 (82.86)

Binary logistic regression analysis.
U: unmethyl, ref: reference, and M: methyl.
OR = odds ratio; 95% CI = 95% confidence interval.
NC: not calculated.