Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress

Figure 2

Hypoxia induces increases in MCP-1 and CCL-11 which is depressed by LBI pretreatment. ELISA was used to measure several cytokines in the conditioned culture media (). No significant changes are observed for IL-8 with the addition of CoCl₂ or LBI pretreatment (a). An increase in the IL-6 was observed after the addition of CoCl₂ while IL-6 decreases with the addition of CoCl₂ after LBI pretreatment (b). The significant increase in the MCP-1 observed after the addition of CoCl₂. But it disappeared with LBI pretreatment (c). A similar tendency was also observed for CCL-11 (d). , , nonrepeated ANOVA. CCL-11, Chemokine (C-C Motif) Ligand 11; IL, interleukin; LBI, lecithin-bound iodine; MCP-1, monocyte chemoattractant protein-1. n.s, not significant.

(a)  

(b)

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