Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress

Figure 4

LBI can protect tight junctions from VEGF. Fifty pg/mL of VEGF was added to culture medium for 6 hrs. ARPE-19 cells ((a)–(d)) were stained with anti-ZO-1 antibody and TJs conformation was evaluated. Note that TJs breakdown was observed after VEGF ((b) arrows). LBI pretreatment before VEGF addition could protect TJs from disruption (d). LBI, lecithin-bound iodine; TJs, tight junctions; VEGF; vascular endothelium growth factor; ZO-1, zonular occludin-1.

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