Retinitis Pigmentosa: Disease Mechanisms, Diagnosis, and Therapies
1Glasgow Caledonian University, Glasgow, UK
2University of Florida, Gainesville, USA
3Sichuan Academy of Medical Sciences, Chengdu, China
4Inverclyde Royal Hospital, Greenock, UK
Retinitis Pigmentosa: Disease Mechanisms, Diagnosis, and Therapies
Description
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder, characterized by impaired dark adaption and progressive loss of photoreceptor cells. Recent studies using in vitro and in vivo models have accelerated the understanding of disease mechanisms of RP. New technologies (e.g., next generation sequencing) have helped identify novel RP-causing genes and diagnose new RP cases. Advanced imaging diagnostics, successful therapies in animal models, and clinical trials offer hope for RP patients.
We invite investigators to contribute original research papers as well as review articles that will promote the understanding of the pathogenesis, the designing of diagnostic platforms, and the development of new therapeutic strategies. We are particularly interested in articles describing the signalling pathways involved in the disease process, the new high-resolution retinal imaging tools, the molecular diagnostics, and the treatments using small chemicals, natural products, stem cells, and gene therapies.
Potential topics include, but are not limited to:
- The role of protein trafficking in RP
- Disease mechanisms from animal models
- Latest technologies for identifying novel RP-causing genes and diagnosing new RP cases
- Adaptive optics retinal imaging in RP
- Gene therapies for RP
- Embryonic stem cell and induced pluripotent stem cell replacement for RP