Testosterone and the Male Skeleton: A Dual Mode of Action

Table 2

Overview of cohort studies in men.

	Average age of men	Number of men	Study duration	LC-MS-MS	Immunoassay	Main result
Rancho Bernardo study [8]	66	352	12 yr		x	(i) E: strong correlation with fractures (ii) T: no correlation with fractures
Dubbo study [9]	>60	609	16 yr	x		(i) T: no correlation with fractures; (ii) E: strong correlation with fractures
Tromso [10]	50–84	1364	8.4 yr		x	T, E, SHBG: no correlation with fractures
Rotterdam study [11]	67.7 ± 6.8	178	6.5 yr		x	T, E, SHBG: no correlation with fractures
Framingham study [12]	71	793	18 yr		x	(i) E: strong correlation with fractures (ii) T + E: strong correlation with fractures
MrOS study [13]	75	2639	3.3 yr	x		E, SHBG: strong correlation with fractures

E: estrogen; T: testosterone; SHBG: sex hormone binding globulin.