The Effects of Parathyroid Hormone Applied at Different Regimes on the Trochanteric Region of the Femur in Ovariectomized Rat Model of Osteoporosis
Table 1
Study results. Body weight, mineral content, biomechanical test, and serum analysis of anabolic bone parameters.
SHAM
OVX
PTH 5x/w
PTH e2d
Mean
STD
Mean
STD
Mean
STD
Mean
STD
Body weight
Before OVX (g)
247.1
8.17
236.7
19.71
240.0
14.67
246.6
10.41
At the end of trial (g)
274.3
15.91
341.0
23.64
341.4
24.95
346.2
32.48
Mineral content (after ashing) in left femurs (%)
49.68
1.93
45.80
1.68
49.54
1.89
48.30
1.41
Biomechanical test
(N)
187.0
20.81
169.3
25.38
194.1
22.78
176.3
17.97
Stiffness (N/mm)
294.8
68.19
230.2
60.62
347.6
39.78
250.9
20.73
Yield load (N)
120.6
28.67
86.96
26.53
134.6
25.77
110.3
9.6
Serum analysis
Osteocalcin (OC) (ng/mL)
14.59
7.51
17.83
6.67
32.55
6.26
37.43
9.63
Alkaline Phosphatase (AP)
40.90
21.62
59.83
21.62
59.54
15.04
74.27
21.99
OVX (Ovariectomy), (maximal load). The value of the difference between treated and untreated animals was calculated using a one-way ANOVA. values were considered significant. versus OVX, versus sham, and PTH 5x/w versus PTH e2d.
