Review Article
Bone Health in Patients with Multiple Sclerosis
Table 1
Changes in bone cells metabolism and in bone mass/structure in patients with long-term immobilization.
| | Increased | Decreased |
| Osteocytes | Apoptosis | Metabolism and function | | | Repair of microdamage | Osteoblasts | Apoptosis | Activity | | | Synthesis of type I collagen | Osteoclasts | Activity | Apoptosis | Bone homeostasis | Remodeling rate | | | Bone resorption | Bone formation | | | Bone mineral density* | | | Cortical thickness* | | | Cortical density* | | | Trabecular density* |
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*The anatomic location and function of the bone in the skeleton account for the magnitude of skeletal response to immobilization.
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