Bone Mineral Density Accrual Determines Energy Expenditure with Refeeding in Anorexia Nervosa and Supersedes Return of Menses
Table 2
Bone marker, BMD, and hormone data (mean ± SD).
Characteristic
Patients with AN at admission ()
Patients with AN at 90% IBW ()
Amenorrheics at 90% IBW ()
Regained menses at 90% IBW ()
Controls ()
Osteocalcina (ng/mL)
8.1 ± 3.0
11.1 ± 5.9
11.4 ± 6.6
10.1 ± 3.6
8.7 ± 3.6
(33)
(34)
(25)
(9)
(12)
Urine NTXb,d (nmol/mmol Cr)
72.4 ± 32.7
70.9 ± 46.8
80.0 ± 50.3
45.9 ± 22.7
48.3 ± 14.4
(34)
(30)
(22)
(8)
(11)
Total BMDb,c (g/cm2)
1.05 ± 0.09
1.05 ± 0.09
1.04 ± 0.09
1.07 ± 0.06
1.13 ± 0.05
(37)
(37)
(27)
(10)
(16)
Spine BMDa,b,c (g/cm2)
0.89 ± 0.15
0.94 ± 0.14
0.92 ± 0.14
0.98 ± 0.13
1.07 ± 0.09
(37)
(37)
(27)
(10)
(16)
Pelvis BMDa,b,c (g/cm2)
0.91 ± 0.13
0.94 ± 0.12
0.93 ± 0.12
0.98 ± 0.09
1.07 ± 0.06
(37)
(37)
(27)
(10)
(16)
Legs BMDb,c (g/cm2)
1.10 ± 0.15
1.09 ± 0.13
1.07 ± 0.14
1.12 ± 0.09
1.19 ± 0.07
(37)
(37)
(27)
(10)
(16)
IGF-1a,c (ng/ml)
244.4 ± 103.1
343.6 ± 120.1
345.7 ± 121.4
337.6 ± 123.2
247.9 ± 76.5
(34)
(35)
(26)
(9)
(12)
Leptina (ng/ml)
2.9 ± 2.7
14.7 ± 17.8
13.1 ± 15.6
19.3 ± 23.8
11.5 ± 5.9
(28)
(31)
(23)
(8)
(10)
Ghrelina (pg/ml)
2025 ± 748
1567 ± 669
1588 ± 654
1835 ± 1213
1738 ± 542
(24)
(25)
(21)
(4)
(11)
LHa,b (mIU/ml)
1.4 ± 2.9
2.8 ± 2.8
2.5 ± 2.7
3.6 ± 3.1
4.0 ± 2.3
(30)
(35)
(25)
(10)
(13)
FSHa,b(mIU/ml)
1.8 ± 2.1
2.7 ± 1.5
2.6 ± 1.3
3.0 ± 1.8
3.9 ± 1.3
(29)
(34)
(24)
(10)
(13)
Estradiola,b,c,d (pg/ml)
23.7 ± 6.4
32.4 ± 14.0
28.2 ± 10.1
42.7 ± 17.3
52.4 ± 31.7
(32)
(35)
(25)
(10)
(14)
Testosterone (ng/dl)
76.2 ± 36.7
81.8 ± 36.7
79.3 ± 38.6
89.1 ± 31.8
63.1 ± 21.0
(26)
(31)
(23)
(8)
(16)
DHEAS (μg/dl)
153.1 ± 59.6
142.0 ± 81.1
139.8 ± 86.9
150.2 ± 59.3
175.8 ± 78.3
(25)
(29)
(23)
(6)
(16)
Cortisola (μg/dl)
20.5 ± 5.5
16.7 ± 6.3
16.6 ± 5.9
16.2 ± 7.6
12.0 ± 4.3
(24)
(27)
(21)
(6)
(10)
TSH (mIU/L)
2.0 ± 1.2
1.7 ± 1.0
1.9 ± 1.0
1.2 ± 0.4
1.9 ± 1.0
(23)
(26)
(21)
(5)
(12)
Total a (ng/dl)
76.8 ± 18.3
106.0 ± 28.3
103.8 ± 27.8
113.9 ± 30.9
120.1 ± 22.9
(27)
(32)
(25)
(7)
(12)
Free b (ng/dl)
1.0 ± 0.2
1.0 ± 0.2
1.0 ± 0.2
1.0 ± 0.1
1.1 ± 0.1
(27)
(32)
(25)
(7)
(12)
Significance set at for all comparisons and is noted in the table.
aSignificant difference between patients with AN at admission and patients with AN at 90% IBW.
bSignificant difference between patients with AN at 90% IBW and controls.
cSignificant difference between amenorrheics at 90% IBW and controls.
dSignificant difference between amenorrheics at 90% IBW and regained menses at 90% IBW.
