Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Table 4

Overview of the biomechanical parameters over time.

Group	Biomechanical parameter	9 months (mean ± SD)	𝑃	12 months (mean ± SD)
ODW	ML (N)	124.2 ± 12.1	^†𝑃 = 0.002	112.6 ± 8.9
	YP (N)	113.0 ± 11.4	NS	105.7 ± 9.0
	SC (N/mm)	214.2 ± 19.0	^†𝑃 = 0.002	236.2 ± 24.4
			^§𝑃 < 0.001
OZA	ML (N)	141.4 ± 9.8	^†𝑃 = 0.003	138.7 ± 9.1
	YP (N)	129.7 ± 6.0	^†𝑃 = 0.02	119.8 ± 9.7
	SC (N/mm)	158.2 ± 9.1	^†𝑃 < 0.001	176.4 ± 6.7
SDW	ML (N)	140.0 ± 6.6	^†§𝑃 < 0.001	118.4 ± 10.5
	YP (N)	125.3 ± 9.1	^†𝑃 = 0.01	112.6 ± 6.2
	SC (N/mm)	171.7 ± 15.3	^†𝑃 < 0.001	219.1 ± 7.0
SZA	ML (N)	149.7 ± 4.3	NS	151.0 ± 9.7
	YP (N)	137.0 ± 10.7	NS	124.6 ± 16.8
	SC (N/mm)	130.1 ± 29.0	^§𝑃 < 0.001	153.4 ± 12.3
			^†𝑃 = 0.01

^†Longitudinal study design (paired t-test).
^§Cross-sectional study design (ANOVA; Holm-Sidak’s post hoc).
NS: no significance.