Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice

Table 1

Basic characteristics from DXA scanning, three-point-bending test, and bone marker analysis.

	𝑁	Mean	SEM	𝑁	Mean	SEM	𝑃
B6	B6^+/+			B6^−/−			𝑡-Test
Body weight (g)	15	20.12	0.45	14	21.65	1.63	0.380
Lean tissue (g)	15	15.6	0.3	14	15.7	0.4	0.786
Fat tissue (g)	15	4.2	0.3	14	5.5	1.5	0.427
Fat percentage	15	20.8	1.3	14	22.7	3.1	0.587
Bone area (cm^2)	15	9.10	0.10	14	9.07	0.14	0.847
Whole body BMC (g)	15	0.454	0.007	14	0.473	0.012	0.179
Whole body BMD (g/cm^2)	15	0.0499	0.000	14	0.0521	0.0006	0.005
Femur length (mm)	15	15.50	0.05	13	15.66	0.21	0.500
Femoral BMC (g)	15	0.036	0.001	14	0.037	0.001	0.321
Femoral BMD (g/cm^2)	15	0.0650	0.0007	14	0.0682	0.0012	0.038
Maximal load (𝑁)	15	16.29	0.29	14	18.22	0.68	0.018
RatLabs (ng/mL)	15	9.7	0.5	14	9.1	0.6	0.441
ALP concentration (nmol/mL)	12	247.6	13.5	13	241.0	12.7	0.727
Osteocalcin (ng/mL)	15	39.2	2.9	14	44.5	2.4	0.161
BALB/cJ	BALB/cJ^+/+			BALB/cJ^−/−			𝑡-Test
Body weight (g)	14	20.68	0.28	15	20.42	0.25	0.499
Lean tissue (g)	14	16.3	0.2	15	16.1	0.2	0.555
Fat tissue (g)	14	3.6	0.1	15	3.3	0.1	0.069
Fat percentage	14	18.0	0.4	15	17.0	0.4	0.086
Bone area (cm^2)	14	9.19	0.08	15	9.90	0.13	<0.001
Whole body BMC (g)	14	0.471	0.008	15	0.558	0.009	<0.001
Whole body BMD (g/cm^2)	14	0.0513	0.0005	15	0.0563	0.0005	<0.001
Femur length (mm)	14	15.06	0.17	15	15.61	0.16	0.029
Femoral BMC (g)	14	0.040	0.001	15	0.044	0.001	0.004
Femoral BMD (g/cm^2)	14	0.0764	0.0006	15	0.0826	0.0010	<0.001
Maximal load (𝑁)	14	24.62	0.44	15	33.95	0.59	<0.001
RatLabs (ng/mL)	14	19.1	1.2	15	8.8	0.5	<0.001
ALP concentration (nmol/mL)	14	314.2	11.0	14	270.6	15.0	0.028
Osteocalcin (ng/mL)	14	55.9	3.1	15	63.2	2.9	0.101