Potential Extensions of the US FRAX Algorithm

Table 4

First nonpathologic fracture of each type observed and hazard ratio (HR) per 10% increase in the full 10-year US FRAX (FN BMD) probability among Rochester, MN women and men ≥40 years of age, by type of fracture outcome.

Fracture type	Women		Men
	Observed	HR (95% CI)	Observed	HR (95% CI)
Any major osteoporotic fracture^a	44	1.9 (1.5–2.4)	18	2.1 (0.99–4.6)
Symptomatic vertebral fracture^b	15	2.2 (1.5–3.3)	7	2.0 (0.5–7.0)
Any asymptomatic vertebral fracture^c	44	1.8 (1.4–2.3)	78	2.4 (1.6–3.6)
Any other fracture^c	61	1.4 (1.1–1.8)	33	1.7 (0.9–3.1)
Other axial fracture	34	1.9 (1.4–2.5)	20	2.1 (1.0–4.2)
Other appendicular fracture^d	33	1.2 (0.9–1.6)	16	2.3 (1.0–5.0)
Any nonpathologic fracture	110	1.6 (1.4–1.9)	104	2.3 (1.6–3.3)

^aDefined according to FRAX as proximal femur, clinical spine, distal forearm, or proximal humerus fractures.
^bIncluded in major osteoporotic fractures.
^cNot included in major osteoporotic fractures.
^dExcluding 2 pathologic appendicular fractures.