Journal of Osteoporosis

Clinical Study

Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population: A Pilot Study

Table 3

(a) Demographic data of TNFRSF11B (C_11869235_10) of AA, AG, and GG allele. (b) Statistical analysis of the TNFRSF11B (C_11869235_10) 3 alleles.
(a)
ParameterAA (114)AG (80)GG (6)
Age years 6 1 . 6 ± 1 0 . 9 6 1 . 2 ± 9 . 8 69.5±12
BMD hip g/cm2 0 . 4 6 1 ± 0 . 1 5 0 . 4 4 3 ± 0 . 1 6 0 . 7 2 6 ± 0 . 5 5
T score − 2 . 7 ± 1 . 2 7 − 2 . 7 5 ± 0 . 9 6 − 1 . 1 ± 2 . 5
Z score − 1 . 3 3 ± 0 . 9 6 − 1 . 2 1 ± 0 . 9 2 − 0 . 1 5 ± 2 . 7
BMD spine g/cm2 0 . 6 8 6 ± 0 . 1 3 0 . 6 8 9 ± 0 . 1 1 0 . 9 1 5 ± 0 . 5 3
T score − 3 . 2 ± 1 . 0 − 3 . 1 4 ± 0 . 9 6 − 1 . 1 ± 2 . 7
Z score − 1 . 9 2 ± 1 − 1 . 7 2 ± 1 . 4 − 2 . 3 5 ± 0 . 5
No. of fractures (%)38 (33.3)25 (31.25)3 (50)
AA: homozygous for A allele, AG: heterozygous allele, and GG: homozygous for G allele.
(b)
ParameterAlleles 𝑃 value (CI)
AgeAA versus AG
AA + AG versus GG		0.2
0.001(8.191–8.808)
BMD hipAA versus AG
AA + AG versus GG		0.232
0.001(0.213–0.333)
BMD spineAA versus AG
AA + AG versus GG		0.77
0.001 (0.16–0.291)
History of fracturesAA versus AG
AA + AG versus GG		0.009 (12.94–13.059)
0.001 (59.85–60.146)