Association between P2X7 Receptor Polymorphisms and Bone Status in Mice
Figure 1
Bone parameters in the 129X1/SvJ, BALB/c, B6, and DBA/2 inbred strains. Significant difference between the strains at the level is indicated with asterisks when different from the three other strains, with A when different from 129X1/SvJ, with B when different from B6, with C when different from BALB/cJ, and with D when different from DBA/2. P451L genotype indicated as P or L at each strain. (a) In BALB/c and B6 whole body BMDs were not significantly different from each other, but significantly lower than 129X1/SvJ and BALB/cJ. BALB/cJ had higher BMD than DBA. (b) The femoral BMD in 129X1/SvJ and BALB/cJ were significantly higher than B6 and DBA/2. The latter were not significantly different from each other. (c) The femoral strength assessed by a three-point bending test showed significantly higher strength in 129X1/SvJ femurs. BALB/c had stronger femurs than the DBA and B6 strains had. The latter two were not significantly different from each other. (d) The serum concentration of the resorption marker s-CTX-I, showed significantly higher resorption in the BALB/cJ strain and lowest in the B6 strain.
