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Journal of Osteoporosis
Volume 2012 (2012), Article ID 672403, 8 pages
http://dx.doi.org/10.1155/2012/672403
Research Article

Normative Data for Bone Mass in Healthy Term Infants from Birth to 1 Year of Age

1School of Dietetics and Human Nutrition, McGill University, 21111 Lakeshore Road, Ste-Anne-de-Bellevue, QC, Canada H9X 3V9
2Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2

Received 13 June 2012; Revised 25 August 2012; Accepted 26 August 2012

Academic Editor: E. M. Lewiecki

Copyright © 2012 Sina Gallo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

For over 2 decades, dual-energy X-ray absorptiometry (DXA) has been the gold standard for estimating bone mineral density (BMD) and facture risk in adults. More recently DXA has been used to evaluate BMD in pediatrics. However, BMD is usually assessed against reference data for which none currently exists in infancy. A prospective study was conducted to assess bone mass of term infants (37 to 42 weeks of gestation), weight appropriate for gestational age, and born to healthy mothers. The group consisted of 33 boys and 26 girls recruited from the Winnipeg Health Sciences Center (Manitoba, Canada). Whole body (WB) as well as regional sites of the lumbar spine (LS 1–4) and femur was measured using DXA (QDR 4500A, Hologic Inc.) providing bone mineral content (BMC) for all sites and BMD for spine. During the year, WB BMC increased by 200% ( versus  g), spine BMC by 130% ( versus  g), and femur BMC by 190% ( versus  g). Spine BMD increased by 14% ( versus  g/cm2) during the year. This data, representing the accretion of bone mass during the first year of life, is based on a representative sample of infants and will aid in the interpretation of diagnostic DXA scans by researchers and health professionals.