- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Osteoporosis
Volume 2012 (2012), Article ID 675984, 5 pages
Osteoporosis in Men
1INSERM UMR 1033, Hôpital Edouard Herriot, University of Lyon, Pavillon F, Place d’Arsonval, 69437 Lyon, France
2Department of Endocrinology, University Hospital Ghent, B-9000 Gent, Belgium
3Department of Medicine, Endocrinology, Diabetology & Clinical Nutrition, Oregon Health & Science University, Portland, OR 97239, USA
Received 24 January 2012; Accepted 24 January 2012
Copyright © 2012 Pawel Szulc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Osteoporotic fractures (fragility fractures) are more frequent in postmenopausal women than in older men . However, osteoporosis in men is one of the major and the most neglected public health problems for several reasons.
First, morbidity, mortality, and loss of independence after major fragility fracture are greater in men than women [2, 3]. The interpretation of data concerning mortality after fragility fracture should be, however, cautious. As life expectancy is lower in men than women, it is not appropriate to compare mortality after hip fracture between men and women of the same age. Therefore, it is important that, for a given age, the additional increase in mortality after a hip fracture is greater in men than women . In addition, the fraction of the potential time of life lost after a hip fracture (taking into account the sex-specific life expectancy) is greater in men than women . Thus, these studies show that the mortality after a hip fracture is really higher in men than in women.
Secondly, the number of osteoporotic fractures in men increases rapidly. The overall number of fractures is on the rise because the elderly population increases due to the lengthening of the lifespan. However, several studies have shown that the age-specific incidence of major osteoporotic fractures in postmenopausal women, especially hip fracture, has been slightly, but consistently, decreasing for the last 15 years [6–8]. Such trends have been observed in North America, Australia, and several European countries. By contrast, in these countries, the age-specific incidence of hip fracture in men decreased less than in women or even remained stable [8–10]. In addition, in some European countries and in Japan, age-specific hip fracture incidence continues to increase in both sexes [11, 12]. Therefore, over the next decades, the number of osteoporotic fractures is expected to increase faster in men than in women. Consequently, fragility fractures in men will constitute higher percentage of all the osteoporotic fractures than they do now.
Thirdly, the identification of men at high risk of fracture is not satisfactory. Increasing age, history of fragility fracture, and low bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) are important risk factors of fracture. Nevertheless, only 20% of men who sustain a hip fracture or major osteoporotic fracture have osteoporosis diagnosed by DXA using the sex-specific T-score < −2.5, half as many compared with women from the same cohort [13–15].
The diagnostic criteria of osteoporosis in men are a matter of controversy. The International Society for Clinical Densitometry (ISCD) recommends sex-specific T-score <−2.5 . By contrast, International Osteoporosis (IOF) recommends the threshold corresponding to T-score = −2.5 in premenopausal women . It corresponds to a T-score of approximately −2.75 compared with peak BMD in young men. The justification for using a female-based threshold is that the risk of fracture is similar in both sexes for the same absolute BMD, not for the same sex-specific T-score. If we accept the threshold recommended by ISCD, men with lower risk of fracture will be treated and we will have to treat more men to avoid one fracture. If we accept the threshold recommended by IOF, fewer men will be treated and fewer fractures will be avoided. Does it mean that the threshold of ISCD should be preferred? Not necessarily. Aside from the individual fracture risk, there is also variation from country to country in the willingness to pay for therapy and in the choice of the treatment criterion. If the sex-specific T-score = −2.5 identifies men at a lower risk of fracture than women, the health authorities may refuse the reimbursement of any antiosteoporotic treatment in men. If the IOF threshold is recommended in these countries, it will be easier to obtain the reimbursement for the osteoporosis treatment in men. Fewer men will be treated, but at least, it will be possible to reduce the risk of fracture in those who have the most severe osteoporosis and the highest risk of fracture.
An additional problem is that other bone parameters do not provide much improvement in the prediction of fracture in men. Classical biochemical bone turnover markers (BTMs) are not predictive of fracture in the multivariable models adjusted for BMD [18, 19]. Ultrasound parameters predict fractures in men similarly to BMD, but their joint use does not improve fracture prediction compared with BMD alone . Quantitative computed tomography (QCT) predicts hip fracture, but not better than DXA alone . Young healthy men with prevalent fractures had lower cortical bone volume assessed by peripheral QCT than men without fracture . However, these analyses were not adjusted for BMD measured by DXA. High-resolution peripheral quantitative computed tomography (HR-pQCT) allows assessment of bone microarchitecture at the distal radius and tibia. Men with vertebral fractures had thinner cortex and lower cortical volumetric BMD assessed by HR-pQCT compared with men without vertebral fracture, even after adjustment for BMD measured by DXA . However, these cross-sectional data have to be confirmed in the prospective studies.
Several studies have assessed other approaches that aimed to improve fracture prediction in men. The FRAX algorithm is a significant landmark in the assessment of the individual risk of fracture . It takes into account several risk factors, which determine bone fragility, for example, history of fracture, parental history of hip fracture, corticotherapy, and so forth. Another algorithm is the Garvan nomogram . It takes into account history of fractures and that of falls. Falls, especially multiple falls, seem to be associated with a substantial increase in the risk of peripheral fracture in the elderly men . However, both FRAX and the Garvan nomogram have been introduced only recently and few studies assessed their utility in men [27, 28].
Limited data suggest an association between bone size and risk of fracture. Low bone width was associated with higher risk of fracture independently of BMD . History of fracture was associated with lower cross-sectional area (CSA) measured by peripheral QCT . However, no method of measurement of bone width or CSA could be recommended currently for the clinical practice. Several studies showed that longer femoral neck axis and wider neck-shaft angle were associated with higher risk of hip fracture, mainly cervical fracture [30, 31]. However, these associations were weak and not consistent between the investigated groups.
More and more studies suggest utility of the finite element analysis (FEA) for fracture prediction in men. The load-to-strength ratio remained significantly associated with the risk of hip fracture after adjustment for BMD . More recently, vertebral compressive strength improved vertebral fracture risk assessment in comparison with DXA-measured BMD . However, FEA is not available in the clinical practice.
Serum and urinary levels of C-terminal telopeptide of type I collagen did not predict fracture after adjustment for BMD in men. By contrast, measurement of serum levels of native, nonisomerized form of CTX-I (α-CTX-I) and of beta-isomerized form (β-CTX-I) showed that higher α-CTX-I/β-CTX-I ratio is associated with higher risk of fracture in men . However, it is not clear if the increased α-CTX-I/β-CTX-I ratio reflects higher bone turnover rate or an intrinsic defect of posttranslational modifications of bone collagen. The use of these measures has not been shown to improve the prediction of fracture or the management of care in men with osteoporosis.
In most of the cohorts, decreased levels of total or bioavailable 17β-estradiol were associated with higher risk of fragility fracture in men [35–37]. However the analyses were not systematically adjusted for BMD. Decreased serum level of 25-hydroxycholecalciferol was associated with higher risk of hip fracture in American men aged >65 and with higher risk of clinical fracture in Swedish men aged >65 [38, 39]. However, this association was markedly attenuated after adjustment for hip BMD . Low serum level of insulin-like growth factor I (IGF-I) was associated with a higher risk of ostoporotic fracture in men, also after adjustment for BMD . The potential mechanism underlying this association is not clear. This observation is, however, interesting because serum IGF-I concentration was not correlated with BMD in older men [41, 42]. Finally, increased level of fibroblast growth factor 23 was associated with higher risk of nonspine fracture in the elderly men, even after adjustment for confounders including BMD and parathyroid hormone concentration . However, the exact mechanism underlying this association has not been elucidated.
Thus, FRAX appears to improve the assessment of the fracture risk in both sexes; however, it needs to be verified in a higher number of cohorts of men. By contrast, other available studies do not provide reliable methods permitting to identify with a satisfactory probability older men at high risk of fracture.
Fourthly, fewer studies concern the antiosteoporotic treatment in older men compared with the studies carried out in postmenopausal women. Most studies assessed only changes in BMD measured by DXA and in the BTM levels induced by antiosteoporotic treatment [44–48]. Then, the antifracture efficacy of the investigated medications in men is inferred indirectly from these bridging studies by comparing their results with the data obtained previously in postmenopausal women. By contrast, few studies assessed the antifracture efficacy of the antiosteoporotic therapies in men [48–52]. Moreover, some of these studies were not powered to this type of analysis. Some of these studies were observational surveys, not randomized pharmaceutical trials. The effect of the antiosteoporotic medications on the risk of fracture in men was assessed specifically only in few studies. The antifracture efficacy of denosumab and toremifene has been investigated in men receiving androgen-deprivation therapy for prostate cancer [53–55]. In older osteoporotic men, zoledronic acid decreased significantly the incidence of vertebral fractures .
Fifthly, even men with an increase in fracture risk are rarely treated. In men, the parameter that indicates higher risk of fracture most consistently in epidemiological studies is prevalent fragility fracture [26, 57]. A history of osteoporotic fracture is associated with a two- to fourfold higher risk of another osteoporotic fracture. This is a very similar situation to that found in postmenopausal women. However, about 50 percent of women who sustained fragility fracture benefit from bone densitometry and/or antiosteoporotic treatment [58–60]. By contrast, less than 10 percent of men who sustained an osteoporotic fracture will have bone densitometry and/or osteoporotic treatment [58–60]. In some studies, only 1 out of 20 men having sustained a hip fracture (and were hospitalized for this fracture) benefited from bone densitometry and/or antiosteoporotic treatment . Even men receiving chronic glucocorticoid therapy or androgen deprivation therapy are not systematically screened and, whenever appropriate, treated for osteoporosis [61, 62].
In conclusion, on one hand, osteoporosis in older men is a major public health problem. The number of fragility fractures in men is rapidly increasing, the consequences of these fractures are more severe in men than in women, and the identification of men at high risk of fracture is suboptimal. On the other hand, osteoporosis in older men should be considered a neglected public health problem. There are fewer data on the appropriate measures to assess fracture risk, less information on the antifracture efficacy of the available medications in men than in women, and only few men with the evidently increased risk of fracture obtain adequate treatment.
Jean Marc Kaufman
Eric S. Orwoll
- J. A. Baron, M. Karagas, J. Barrett et al., “Basic epidemiology of fractures of the upper and lower limb among americans over 65 years of age,” Epidemiology, vol. 7, no. 6, pp. 612–618, 1996.
- D. P. Kiel, A. Eichorn, O. Intrator, R. A. Silliman, and V. Mor, “The outcomes of patients newly admitted to nursing homes after hip fracture,” American Journal of Public Health, vol. 84, no. 8, pp. 1281–1286, 1994.
- M. Fransen, M. Woodward, R. Norton, E. Robinson, M. Butler, and A. J. Campbell, “Excess mortality or institutionalization after hip fracture: men are at greater risk than women,” Journal of the American Geriatrics Society, vol. 50, no. 4, pp. 685–690, 2002.
- D. Bliuc, N. D. Nguyen, V. E. Milch, T. V. Nguyen, J. A. Eisman, and J. R. Center, “Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women,” Journal of the American Medical Association, vol. 301, no. 5, pp. 513–521, 2009.
- A. Trombetti, F. Herrmann, P. Hoffmeyer, M. A. Schurch, J. P. Bonjour, and R. Rizzoli, “Survival and potential years of life lost after hip fracture in men and age-matched women,” Osteoporosis International, vol. 13, no. 9, pp. 731–737, 2002.
- W. D. Leslie, S. O'Donnell, S. Jean et al., “Trends in hip fracture rates in Canada,” Journal of the American Medical Association, vol. 302, no. 8, pp. 883–889, 2009.
- B. Abrahamsen and P. Vestergaard, “Declining incidence of hip fractures and the extent of use of anti-osteoporotic therapy in Denmark 1997–2006,” Osteoporosis International, vol. 21, no. 3, pp. 373–380, 2010.
- A. A. Fisher, E. D. O'Brien, and M. W. Davis, “Trends in hip fracture epidemiology in Australia: possible impact of bisphosphonates and hormone replacement therapy,” Bone, vol. 45, no. 2, pp. 246–253, 2009.
- M. Maravic, P. Taupin, P. Landais, and C. Roux, “Change in hip fracture incidence over the last 6 years in France,” Osteoporosis International, vol. 22, no. 3, pp. 797–801, 2011.
- T. Chevalley, E. Guilley, F. R. Herrmann, P. Hoffmeyer, C. H. Rapin, and R. Rizzoli, “Incidence of hip fracture over a 10-year period (1991–2000): reversal of a secular trend,” Bone, vol. 40, no. 5, pp. 1284–1289, 2007.
- A. Icks, B. Haastert, M. Wildner, C. Becker, and G. Meyer, “Trend of hip fracture incidence in Germany 1995–2004: a population-based study,” Osteoporosis International, vol. 19, no. 8, pp. 1139–1145, 2008.
- H. Hagino, K. Furukawa, S. Fujiwara et al., “Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan,” Osteoporosis International, vol. 20, no. 4, pp. 543–548, 2009.
- P. Szulc, F. Munoz, F. Duboeuf, F. Marchand, and P. D. Delmas, “Bone mineral density predicts osteoporotic fractures in elderly men: the MINOS study,” Osteoporosis International, vol. 16, no. 10, pp. 1184–1192, 2005.
- S. C. Schuit, M. van der Klift, A. E. Weel et al., “Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam study,” Bone, vol. 34, no. 1, pp. 195–202, 2004.
- H. A. Fink, T. L. Blackwell, B. C. Taylor, et al., “Distribution and rate of clinical fractures in older men without osteoporosis: the osteoporotic fractures in men (MrOS) study,” Journal of Bone and Mineral Research, vol. 23, supplement 1, p. S79, article 1282, 2008.
- Writing Group for the ISCD Position Development Conference, “Diagnosis of osteoporosis in men, premenopausal women, and children,” Journal of Clinical Densitometry, vol. 7, no. 1, pp. 17–26, 2004.
- J. A. Kanis, E. V. McCloskey, H. Johansson, A. Oden, L. J. Melton, and N. Khaltaev, “A reference standard for the description of osteoporosis,” Bone, vol. 42, no. 3, pp. 467–475, 2008.
- P. Szulc, A. Montella, and P. D. Delmas, “High bone turnover is associated with accelerated bone loss but not with increased fracture risk in men aged 50 and over: the prospective MINOS study,” Annals of the Rheumatic Diseases, vol. 67, no. 9, pp. 1249–1255, 2008.
- D. C. Bauer, P. Garnero, S. L. Harrison et al., “Biochemical markers of bone turnover, hip bone loss, and fracture in older men: the MrOS study,” Journal of Bone and Mineral Research, vol. 24, no. 12, pp. 2032–2038, 2009.
- D. C. Bauer, S. K. Ewing, J. A. Cauley, K. E. Ensrud, S. R. Cummings, and E. S. Orwoll, “Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study,” Osteoporosis International, vol. 18, no. 6, pp. 771–777, 2007.
- D. M. Black, M. L. Bouxsein, L. M. Marshall et al., “Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT,” Journal of Bone and Mineral Research, vol. 23, no. 8, pp. 1326–1333, 2008.
- Y. Taes, B. Lapauw, V. Griet et al., “Prevalent fractures are related to cortical bone geometry in young healthy men at age of peak bone mass,” Journal of Bone and Mineral Research, vol. 25, no. 6, pp. 1433–1440, 2010.
- P. Szulc, S. Boutroy, N. Vilayphiou, A. Chaitou, P. D. Delmas, and R. Chapurlat, “Cross-sectional analysis of the association between fragility fractures and bone microarchitecture in older men: the STRAMBO study,” Journal of Bone and Mineral Research, vol. 26, no. 6, pp. 1358–1367, 2011.
- N. D. Nguyen, S. A. Frost, J. R. Center, J. A. Eisman, and T. V. Nguyen, “Development of a nomogram for individualizing hip fracture risk in men and women,” Osteoporosis International, vol. 18, no. 8, pp. 1109–1117, 2007.
- S. Blaizot, P. D. Delmas, F. Marchand, R. Chapurlat, and P. Szulc, “Risk factors for peripheral fractures vary by age in older men-the prospective MINOS study,” Osteoporosis International, vol. 22, pp. 1755–1764, 2011.
- L. A. Fraser, L. Langsetmo, C. Berger et al., “Fracture prediction and calibration of a Canadian FRAX tool: a population-based report from CaMos,” Osteoporosis International, vol. 22, no. 3, pp. 829–837, 2011.
- S. K. Sandhu, N. D. Nguyen, J. R. Center, N. A. Pocock, J. A. Eisman, and T. V. Nguyen, “Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram,” Osteoporosis International, vol. 21, no. 5, pp. 863–871, 2010.
- P. Szulc, F. Munoz, F. Duboeuf, F. Marchand, and P. D. Delmas, “Low width of tubular bones is associated with increased risk of fragility fracture in elderly men—the MINOS study,” Bone, vol. 38, no. 4, pp. 595–602, 2006.
- F. Rivadeneira, J. J. Houwing-Duistermaat, T. J. Beck et al., “The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam study,” Journal of Bone and Mineral Research, vol. 19, no. 8, pp. 1280–1290, 2004.
- P. Pulkkinen, J. Partanen, P. Jalovaara, and T. Jämsä, “BMD T-score discriminates trochanteric fractures from unfractured controls, whereas geometry discriminates cervical fracture cases from unfractured controls of similar BMD,” Osteoporosis International, vol. 21, pp. 1269–1276, 2010.
- E. S. Orwoll, L. M. Marshall, C. M. Nielson et al., “Finite element analysis of the proximal femur and hip fracture risk in older men,” Journal of Bone and Mineral Research, vol. 24, no. 3, pp. 475–483, 2009.
- X. Wang, A. Sanyal, P. M. Cawthon, et al., “Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scans,” Journal of Bone and Mineral Research, vol. 27, no. 4, pp. 808–816, 2012.
- D. C. Bauer, P. Garnero, S. Litwack Harrison, et al., “Type I collagen isomerization (Alpha/Beta CTX Ratio) and risk of clinical vertebral fracture in men: a prospective study,” http://www.asbmr.org/itinerary/presentationdetail.aspx?id=d3262330-281a-4261-b9a7-9a17d3efaf63.
- E. S. LeBlanc, C. M. Nielson, L. M. Marshall et al., “The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, pp. 3337–3346, 2009.
- S. Amin, Y. Zhang, D. T. Felson et al., “Estradiol, testosterone, and the risk for hip fractures in elderly men from the framingham study,” American Journal of Medicine, vol. 119, no. 5, pp. 426–433, 2006.
- D. Mellström, L. Vandenput, H. Mallmin et al., “Older men with low serum estradiol and high serum SHBG have an increased risk of fractures,” Journal of Bone and Mineral Research, vol. 23, no. 10, pp. 1552–1560, 2008.
- J. A. Cauley, N. Parimi, K. E. Ensrud et al., “Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men,” Journal of Bone and Mineral Research, vol. 25, no. 3, pp. 545–553, 2010.
- H. Melhus, G. Snellman, R. Gedeborg et al., “Plasma 25-hydroxyvitamin D levels and fracture risk in a community-based cohort of elderly men in Sweden,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 6, pp. 2637–2645, 2010.
- C. Ohlsson, D. Mellström, D. Carlzon et al., “Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study,” Journal of Bone and Mineral Research, vol. 26, no. 4, pp. 865–872, 2011.
- J. A. Langlois, C. J. Rosen, M. Visser et al., “Association between insulin-like growth factor I and bone mineral density in older women and men: the Framingham heart study,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 12, pp. 4257–4262, 1998.
- P. Szulc, M. O. Joly-Pharaboz, F. Marchand, and P. D. Delmas, “Insulin-like growth factor I is a determinant of hip bone mineral density in men less than 60 years of age: MINOS study,” Calcified Tissue International, vol. 74, no. 4, pp. 322–329, 2004.
- M. A. Mirza, M. K. Karlsson, D. Mellström, et al., “Serum fibroblast growth factor-23 (FGF-23) and fracture risk in elderly men,” Journal of Bone and Mineral Research, vol. 26, no. 4, pp. 857–864, 2011.
- S. Boonen, E. S. Orwoll, D. Wenderoth, K. J. Stoner, R. Eusebio, and P. D. Delmas, “Once-weekly risedronate in men with osteoporosis: results of a 2-Year, placebo-controlled, double-blind, multicenter study,” Journal of Bone and Mineral Research, vol. 24, no. 4, pp. 719–725, 2009.
- E. S. Orwoll, N. C. Binkley, E. M. Lewiecki, U. Gruntmanis, M. A. Fries, and G. Dasic, “Efficacy and safety of monthly ibandronate in men with low bone density,” Bone, vol. 46, no. 4, pp. 970–976, 2010.
- E. S. Orwoll, P. D. Miller, J. D. Adachi et al., “Efficacy and safety of a once-yearly i.v. infusion of zoledronic acid 5mg versus a once-weekly 70-mg oral alendronate in the treatment of male osteoporosis: a randomized, multicenter, double-blind, active-controlled study,” Journal of Bone and Mineral Research, vol. 25, no. 10, pp. 2239–2250, 2010.
- G. P. Trovas, G. P. Lyritis, A. Galanos, P. Raptou, and E. Constantelou, “A randomized trial of nasal spray salmon calcitonin in men with idiopathic osteoporosis: effects on bone mineral density and bone markers,” Journal of Bone and Mineral Research, vol. 17, no. 3, pp. 521–527, 2002.
- E. S. Orwoll, W. H. Scheele, S. Paul et al., “The effect of teriparatide [human parathyroid hormone (1–34)] therapy on bone density in men with osteoporosis,” Journal of Bone and Mineral Research, vol. 18, no. 1, pp. 9–17, 2003.
- E. Orwoll, M. Ettinger, S. Weiss et al., “Alendronate for the treatment of osteoporosis in men,” The New England Journal of Medicine, vol. 343, no. 9, pp. 604–610, 2000.
- J. D. Ringe, A. Dorst, H. Faber, and K. Ibach, “Alendronate treatment of established primary osteoporosis in men: 3-Year results of a prospective, comparative, two-arm study,” Rheumatology International, vol. 24, no. 2, pp. 110–113, 2004.
- Z. M. Zhong and J. T. Chen, “Anti-fracture efficacy of risedronic acid in men: a meta-analysis of randomized controlled trials,” Clinical Drug Investigation, vol. 29, no. 5, pp. 349–357, 2009.
- J. M. Kaufman, E. Orwoll, S. Goemaere et al., “Teriparatide effects on vertebral fractures and bone mineral density in men with osteoporosis: treatment and discontinuation of therapy,” Osteoporosis International, vol. 16, no. 5, pp. 510–516, 2005.
- M. R. Smith, B. Egerdie, N. H. Toriz et al., “Denosumab in men receiving androgen-deprivation therapy for prostate cancer,” The New England Journal of Medicine, vol. 361, no. 8, pp. 745–755, 2009.
- M. R. Smith, R. A. Morton, K. G. Barnette et al., “Toremifene to reduce fracture risk in men receiving androgen deprivation therapy for prostate cancer,” Journal of Urology, vol. 184, no. 4, pp. 1316–1321, 2010.
- M. R. Smith, S. B. Malkowicz, M. K. Brawer, M. L. Hancock, R. A. Morton, and M. S. Steiner, “Toremifene decreases vertebral fractures in men younger than 80 years receiving androgen deprivation therapy for prostate cancer,” Journal of Urology, vol. 186, no. 6, pp. 2239–2244, 2011.
- S. Boonen, G. Su, E. Incera, et al., “Antifracture efficacy and safety of once-yearly zoledronic acid 5 mg in men with osteoporosis: a prospective, randomized, controlled trial,” Osteoporosis International, vol. 22, supplement 1, 2011.
- P. Haentjens, O. Johnell, J. A. Kanis et al., “Evidence from data searches and life-table analyses for gender-related differences in absolute risk of hip fracture after Colles' or spine fracture: Colles' fracture as an early and sensitive marker of skeletal fragility in white men,” Journal of Bone and Mineral Research, vol. 19, no. 12, pp. 1933–1944, 2004.
- M. J. Panneman, P. Lips, S. S. Sen, and R. M. C. Herings, “Undertreatment with anti-osteoporotic drugs after hospitalization for fracture,” Osteoporosis International, vol. 15, no. 2, pp. 120–124, 2004.
- A. C. Feldstein, G. Nichols, E. Orwoll et al., “The near absence of osteoporosis treatment in older men with fractures,” Osteoporosis International, vol. 16, no. 8, pp. 953–962, 2005.
- G. M. Kiebzak, G. A. Beinart, K. Perser, C. G. Ambrose, S. J. Siff, and M. H. Heggeness, “Undertreatment of osteoporosis in men with hip fracture,” Archives of Internal Medicine, vol. 162, no. 19, pp. 2217–2222, 2002.
- M. M. Chitre and W. Hayes, “3-year results of a member and physician intervention to reduce risk associated with glucocorticoid-induced osteoporosis in a health plan,” Journal of Managed Care Pharmacy, vol. 14, no. 3, pp. 281–290, 2008.
- J. E. Brown, J. M. Sherriff, and N. D. James, “Osteoporosis in patients with prostate cancer on long-term androgen deprivation therapy: an increasing, but under-recognized problem,” BJU International, vol. 105, no. 8, pp. 1042–1043, 2010.