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Receptor | Species | Inoculation site | Cell type | Antagonist | Effect of cancer at peripheral sites | Effect of cancer at dorsal root or trigeminal ganglions level | Effect of cancer at spinal cord level | Behavioral Tests | Effect of receptor inhibition on bone cancer pain-related behavior | References |
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| C3H mice | Into and around the calcaneus bone | NCTC 2472 fibrosarcoma cells | | Increased expression (epidermis) (protein) | | | Mechanical | | [41] |
| Fisher rats | Subperiosteal tissue of the lower gingiva | SCC-158 squamous cell carcinoma | | | Increased expression (protein) | | Mechanical Thermal | | [42] |
| C3H/HeJ mice | Tibia | NCTC 2472 fibrosarcoma cells | A-317491 s.c. over tumoral mass | | | | Thermal | Attenuation | [68] |
P2X3, (P2X2/3) | Sprague-Dawley rats | Tibia | MRMT-1 mammary gland carcinoma cells | AF-353 (RO-4) i.t. or p.o. | | | Antagonist: reduction in hyperexcitability | Weight-bearing | Attenuation | [67] |
| Wistar rats | Tibia | Walker 256 cell Breast carcinoma cell | A-317491 i.t. or s.c. with ,-me ATP | | Increased expression (mRNA and protein) | | Mechanical Limb use Flinching | Attenuation | [70] |
| C3H/HeN mice | Femur | NCTC 2472 fibrosarcoma cells | A-317491 s.c. | | | | Weight-bearing Limb use | Attenuation (early phase) | [69] |
| Balb/cJ mice | Femur | 4T1 mammary carcinoma | A-317491 s.c. | | | | Weight-bearing Limb use | Attenuation (early phase) | [69] |
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P2X7 | C3H/HeN mice | Femur | NCTC 2472 fibrosarcoma cells | A-438079 s.c | | | | Weight-bearing Limb use | No effect | [113] |
Balb/cJ mice, WT and KO | Femur | 4T1 mammary carcinoma | A-438079 s.c | | | | Weight-bearing Limb use | No effect | [113] |
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P2Y1 | Sprague-Dawley rats | Tibia | Walker 256 cell Breast carcinoma cell line | MRS2179 i.t. | | Increased expression (mRNA) | Increased expression (mRNA) | Mechanical Limb use | Attenuation | [120] |
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