| | Rank | Paper | Absolute number of citations | Citation density | Level of evidence |
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| | 3 | J. M. Wozney, V. Rosen, A. J. Celeste, and L. M. Mitsock, “Novel regulators of bone-formation - molecular clones and activities,” Science, vol. 242, pp. 528–1534, 1988. | 2662 | 106,4 | N/A |
| | 4 | W. S. Simonet, D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang, R. Luthy, H. Q. Nguyen, S. Wooden, L. Bennett, T. Boone, G. Shimamoto, M. DeRose, R. Elliott, A. Colombero, H. L. Tan, G. Trail, J. Sullivan, E. Davy, N. Bucay, L. Renshaw Gegg, T. M. Hughes, D. Hill, W. Pattison, P. Campbell, S. Sander, G. Van, J. Tarpley, P. Derby, R. Lee, and W. J. Boyle, Cell, vol. 89, pp. 309–319, 1997. | 2629 | 164,3 | N/A |
| | 5 | H. Yasuda, N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, E. Tsuda, T. Morinaga, K. Higashio, N. Udagawa, N. Takahashi, and T. Suda, “Osteoclast differentiation factor is a ligand for osteoprotegerin osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, pp. 3597–3602, 1998. | 2206 | 147 | N/A |
| | 6 | T. Komori, H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Sasaki, K. Deguchi, Y. Shimizu, R. T. Bronson, Y. H. Gao, M. Inada, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, and T. Kishimoto, “Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to aturational arrest of osteoblasts,” Cell, vol. 89, pp. 755–764, 1998. | 2132 | 133,2 | N/A |
| | 7 | S. R. Cumming, M. C. Nevitt, W. S. Browner, K. Stone, K. M. Fox, K. E. Ensrud, J. C. Cauley, D. Black, and T. M. Vogt, “Risk-factors for hip fracture in white women,” The New England Journal of Medicine, vol. 332, pp. 767–773, 1995. | 2102 | 116,7 | I |
| | 8 | D. M. Black, S. R. Cumming, D.B. Karpf, J. A. Cauley, D. E. Thompson, M. C. Nevitt, D. C. Bauer, H. K. Genant, W. L. Haskell, R. Marcus, S. M. Ott, J. C. Torner, S. A. Quandt, T. F. Reiss, and K. E. Ensrud, “Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures,” Lancet, vol. 348, pp. 1535–1541, 1996. | 2067 | 121,5 | I |
| | 9 | M. C. Chapuy, M. E. Arlot, F. Duboeuf, J. Brun, B. Crouzet, S. Arnaud, P. D. Delmas, and P. J. Meunier, “Vitamin-D(3) and calcium to prevent hip-fractures in elderly women,” The New England Journal of Medicine, vol. 23, pp. 1637–1642, 1992. | 1771 | 84,3 | I |
| | 10 | Y. Y. Kong, H. Yoshida, I. Sarosi, H. L. Tan, E. Timms, C. Capparelli, S. Morony, A. J. Oliveira-dos-Santos, G. Van, A. Itie, W. Khoo, A. Wakeham, C. R. Dunstan, D. L. Lacey, T. W. Mak, W. J. Boyle, and J. M. Penninger, “OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis,” Nature, vol. 397, pp. 315–323, 1999. | 1741 | 124,3 | N/A |
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| | 12 | B. L. Riggs, and L. J. Melton, “Involutional Osteoporosis,” The New England Journal of Medicine, vol. 314, pp. 1676–1686, 1986. | 1719 | 63,6 | N/A |
| | 13 | D. Marshall, O. Johnell, and H. Wedel, “Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures,” British Medical Journal, vol. 312, pp. 1254–1259, 1996. | 1689 | 99,3 | I |
| | 14 | R. M. Neer, C. D. Arnaud, J. R. Zanchetta, R. Prince, G. A. Gaich, J. Y. Reginster, A. B. Hodsman, E. F. Eriksen, S. Ish-Shalom, H. K. Genant, O. H. Wang, and B. H. Mitlak, “Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis,” Lancet, vol. 344, pp. 1434–1441, 2001. | 1686 | 140,5 | I |
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| | 16 | W. J. Boyle, W. S. Simonet, and D. L. Lacey, “Osteoclast differentiation and activation,” Cell, vol. 423, pp. 337–342, 2003. | 1651 | 165,1 | N/A |
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| | 18 | J. A. Kanis, L. J. Melton, C. Christiansen, C. C. Johnston, and N. Khaltaev, “Perspective-the diagnosis of osteoporosis,” Cell, vol. 9, pp. 1137–1141, 1994. | 1532 | 80,6 | N/A |
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| | 21 | N. A. Morrison, J. C. Qi, A. Tokita, P. J. Kelly, L. Crofts, T. V. Nguyen, P. N. Sambrook, and J. A. Eisman, “Prediction of bone-density from vitamin-d receptor alleles,” Nature, vol. 367, pp. 284–287, 1994. | 1372 | 72,2 | N/A |
| | 22 | S. L. Teitelbaum, “Bone resorption by osteoclasts,” Science, vol. 289, pp. 1504–1508, 2000. | 1370 | 105,3 | N/A |
| | 23 | N. Bucay, I. Sarosi, C. R. Dunstan, S. Morony, J. Tarpley, C. Capparelli, S. Scully, H. L. Tan, W. L. Xu, D. L. Lacey, W. J. Boyle, and W. S. Simonet, “Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification,” Genes & Development, vol. 12, pp. 1260–1268, 1998. | 1292 | 86,1 | N/A |
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