Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Genes in the Peripheral Blood of Late Postmenopausal Osteoporotic Women

Table 2

Correlation coefficients and their significance () are shown for the expression of cell growth and differentiation-related genes in relation to BMD in postmenopausal osteoporotic women.

	mTOR	TGFβ1	RUNX2	TNFα	IL-1β	Caspase-3
RUNX2	0.768	0.768
	(P < 0.001)	(P < 0.001)
TNFα	0.664		0.504
	(P = 0.005)		(P = 0.03)
IL-1β	0.424	0.696	0.496	0.494
	(P = 0.06)	(P < 0.001)	(P = 0.01)	(P = 0.03)
Caspase-3	0.666	0.481	0.519	0.867	0.637
	(P = 0.003)	(P = 0.03)	(P = 0.01)	(P < 0.001)	(P = 0.002)
p21	0.580	0.868	0.680	0.715	0.675	0.715
	(P = 0.009)	(P < 0.001)	(P = 0.001)	(P = 0.002)	(P = 0.001)	(P = 0.001)
TGFβ1	0.632
	P = 0.004
Cathepsin K	0.542			0.516
	(P = 0.03)			(P = 0.07)
Lumbar spine
Femoral neck
Trochanter			0.548
			(P = 0.01)
Ward triangle			0.516
			(P = 0.02)
Total femur		0.524	0.605
		(P = 0.02)	(P = 0.005)