The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabolism

Figure 10

Antiosteoclastogenic cytokines in women and men. In PHA⁻ cultures, exercise enhanced the production of TGF-β in women and IL-10, IL-6, and TGF-β in men. In PHA⁺ cultures, exercise enhanced the production of IL-4, IL-6, and TGF-β in women and IL-6 and TGF-β in men. The white and black columns represent pre- and postexercise levels, respectively. In both figures, IL-4 and IL-10 values are listed on the left Y axis and IL-6 and TGF-β values on the right Y axis. Results are given as the mean ± SEM. indicates a p value of <.05 (two-sided t-test for dependent samples). Note that, in PHA⁻ cultures, postexercise production of IL-10 and IL-6 is greater in men than in women.