Characteristics Associated with Acute-Phase Response following First Zoledronic Acid Infusion in Brazilian Population with Osteoporosis
Table 1
Demographic and clinical characteristics of 428 patients with data on CTX according to the presence or absence of registered APR data about zoledronic acid infusion acute-phase response.
Characteristics
Registered APR data
value
Yes
No
Patients, n (%)
400
28
Female, n (%)
318 (79.5)
22 (78.6)
0.90
Age (years); mean ± SD
70.3 ± 11.2
72.9 ± 10.9
0.24
Oral bisphosphonate-prior use, n (%)
184 (46.0%)
12 (42.9%)
0.75
BMI (kg/m2), mean ± SD
25.83 ± 4.8
26.42 ± 5.8
0.73
Diabetes, n (%)
59 (14.7%)
08 (28.7%)
0.09
Smoking, n (%)
Never
227 (57.0%)
11 (39.3%)
0.15
Former
141 (35.4%)
13 (46.4%)
Active
30 (7.5%)
4 (14.3%)
25-Hydroxyvitamin D, median [25–75th percentile]
Baseline (ng/mL)
33.6 [25.0, 39.0]
33.9 [25.0, 38.0]
0.83
After infusion (ng/mL)
32.6 [24.0, 38.0]
33.9 [24.8, 41.0]
0.57
Total calcium (mg/dL), median [25–75th percentile]
9.3 [8,9, 9.5]
9.3 [9.1, 9.5]
0.61
PTH, median [25–75th percentile]
55.3 [39.0, 62.0]
52.6 [36.3, 66.0]
0.61
eGFR level (mL/min), mean ± SD
60 ± 16
59 ± 20
0.64
CTX, median [25–75th percentile]
Baseline, ng/mL
0.517 [0.314, 0.695]
0.617 [0.416, 0.743]
0.13
After infusion, ng/mL
0.218 [0.123, 0.267]
0.351 [0.187, 0.429]
0.06
BMI, body mass index; PTH, parathyroid hormone; eGFR, estimated glomerular filtration rate, measured by CKD-EPI creatinine equation; CTX, carboxy-terminal crosslinked telopeptide of type 1 collagen.
