Research Article
Testosterone and the Male Skeleton: A Dual Mode of Action
Table 2
Overview of cohort studies in men.
| | Average age of men | Number of men | Study duration | LC-MS-MS | Immunoassay | Main result |
| Rancho Bernardo study [8] | 66 | 352 | 12 yr | | x | (i) E: strong correlation with fractures (ii) T: no correlation with fractures | Dubbo study [9] | >60 | 609 | 16 yr | x | | (i) T: no correlation with fractures (ii) E: strong correlation with fractures |
Tromso [10] | 50–84 | 1364 | 8.4 yr | | x | T, E, SHBG: no correlation with fractures | Rotterdam study [11] | 67.7 ± 6.8 | 178 | 6.5 yr | | x | T, E, SHBG: no correlation with fractures | Framingham study [12] | 71 | 793 | 18 yr | | x | (i) E: strong correlation with fractures (ii) T + E: strong correlation with fractures | MrOS study [13] | 75 | 2639 | 3.3 yr | x | | E, SHBG: strong correlation with fractures |
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E: estrogen; T: testosterone; SHBG: sex hormone binding globulin.
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