Review Article
Strategies for Diagnosis and Prevention of Venous Thromboembolism during Pregnancy
Table 5
Unique aspects that need to be considered for thromboprophylaxis during pregnancy.
| (1) Transplacental transfer | (2) Expanded blood volume up to 50% | (3) Increase in volume of distribution | (4) Increase in GFR leading to enhanced excretion of heparin | (5) Enhanced protein binding of heparin | (6) Shorter half lives of UFH and LMWH—higher and frequent dose requirement | (7) Risk of heparin-induced thrombocytopenia (also known as HIT) |
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