Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds
Figure 1
High levels of HAQs are produced in P. aeruginosa infected burn wounds. (a) Hematoxylin and eosin stained sections of right lower extremity biopsy specimen demonstrating active deep infection with myonecrosis and inflammatory infiltrate (10x) (b) Oil immersion view of the same specimen demonstrating myonecrosis with proliferating rods. Note the presence of intramuscular bacteria (inset). HHQ, PQS and HQNO levels measured in two operative specimens, necrotic muscle with fat (c) and pus and liquefied fat (d); and from the collected drainage liquid (e) obtained from an infected burn wound on the patient’s right leg. Notably, HAQs were detected in the drainage liquid at a magnitude similar to that encountered in bacterial broth cultures.
