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Linked References

1. J. He, M. E. Bose, E. T. Beck et al., “Rapid multiplex reverse transcription-PCR typing of influenza A and B virus, and subtyping of influenza A virus into H1, 2, 3, 5, 7, 9, N1 (human), N1 (animal), N2, and N7, including typing of novel swine origin influenza A (H1N1) virus, during the 2009 Outbreak in Milwaukee, Wisconsin,” Journal of Clinical Microbiology, vol. 47, no. 9, pp. 2772–2778, 2009. View at Publisher · View at Google Scholar · View at Scopus
2. C. Fraser, C. A. Donnelly, S. Cauchemez et al., “Pandemic potential of a strain of influenza A (H1N1): early findings,” Science, vol. 324, no. 5934, pp. 1557–1561, 2009. View at Publisher · View at Google Scholar · View at Scopus
3. J. R. Coleman, “The PB1-F2 protein of Influenza A virus: increasing pathogenicity by disrupting alveolar macrophages,” Virology Journal, vol. 4, article 9, 2007. View at Publisher · View at Google Scholar · View at Scopus
4. CDC, “Outbreak of swine-origin influenza A (H1N1) virus infection—Mexico, March- April 2009,” Morbidity and Mortality Weekly Report, vol. 58, pp. 463–466, 2009.
5. S. U. Schnitzler and P. Schnitzler, “An update on swine-origin influenza virus A/H1N1: a review,” Virus Genes, vol. 39, no. 3, pp. 279–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
6. G. Neumann, T. Noda, and Y. Kawaoka, “Emergence and pandemic potential of swine-origin H1N1 influenza virus,” Nature, vol. 459, no. 7249, pp. 931–939, 2009. View at Publisher · View at Google Scholar · View at Scopus
7. CDC, CDC Estimates of 2009 H1N1 Influenza Cases, Hospitalizations and Deaths in the United States, CDC—H1N1 General Info, Atlanta, Ga, USA, 2009.
8. D. A. Steinhauer and J. J. Skehel, “Genetics of influenza viruses,” Annual Review of Genetics, vol. 36, pp. 305–332, 2002. View at Publisher · View at Google Scholar · View at Scopus
9. J. Lu, D. Liu, W. Liu, T. Shi, Y. Tong, and W. Cao, “Genetic stability and linkage analysis of the 2009 influenza A(H1N1) virus based on sequence homology,” Archives of Virology, vol. 154, no. 12, pp. 1883–1890, 2009. View at Publisher · View at Google Scholar · View at Scopus
10. R. J. Garten, C. T. Davis, C. A. Russell et al., “Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans,” Science, vol. 325, no. 5937, pp. 197–201, 2009. View at Publisher · View at Google Scholar · View at Scopus
11. C. J. Russell and R. G. Webster, “The genesis of a pandemic influenza virus,” Cell, vol. 123, no. 3, pp. 368–371, 2005. View at Publisher · View at Google Scholar · View at Scopus
12. T. G. Ksiazek, D. Erdman, C. S. Goldsmith et al., “A novel coronavirus associated with severe acute respiratory syndrome,” The New England Journal of Medicine, vol. 348, no. 20, pp. 1953–1966, 2003. View at Publisher · View at Google Scholar · View at Scopus
13. M. D. Wang and A. M. Jolly, “Changing virulence of the SARS virus: the epidemiological evidence,” Bulletin of the World Health Organization, vol. 82, no. 7, pp. 547–548, 2004. View at Scopus
14. D. Wang, L. Coscoy, M. Zylberberg et al., “Microarray-based detection and genotyping of viral pathogens,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 24, pp. 15687–15692, 2002. View at Publisher · View at Google Scholar · View at Scopus
15. P. Elias, “Gene chip helps identify cause of mystery illness,” in Associated Press: USA Today, 2003.
16. K. V. Holmes, “Lai MMC,” in Fields' Virology, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2001.
17. J. T. F. Lau, H. Tsui, M. Lau, and X. Yang, “SARS transmission, risk factors, and prevention in Hong Kong,” Emerging Infectious Diseases, vol. 10, no. 4, pp. 587–592, 2004. View at Scopus
18. J. T. F. Lau, X. Yang, H. Tsui, and E. Pang, “SARS preventive and risk behaviours of Hong Kong air travellers,” Epidemiology and Infection, vol. 132, no. 4, pp. 727–736, 2004. View at Publisher · View at Google Scholar · View at Scopus
19. T. M. Uyeki, “2009 H1N1 virus transmission and outbreaks,” The New England Journal of Medicine, vol. 362, no. 23, pp. 2221–2223, 2010. View at Scopus
20. D. A. Janies, I. O. Voronkin, J. Studer et al., “Selection for resistance to oseltamivir in seasonal and pandemic H1N1 influenza and widespread co-circulation of the lineages,” International Journal of Health Geographics, vol. 9, article 13, 2010. View at Publisher · View at Google Scholar · View at Scopus
21. L. V. Gubareva, R. G. Webster, and F. G. Hayden, “Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants,” Antimicrobial Agents and Chemotherapy, vol. 45, no. 12, pp. 3403–3408, 2001. View at Publisher · View at Google Scholar · View at Scopus
22. http://www.cdc.gov/flu/weekly/fluactivity.htm.
23. S. Mueller, J. R. Coleman, and E. Wimmer, “Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis,” Chemistry and Biology, vol. 16, no. 3, pp. 337–347, 2009. View at Publisher · View at Google Scholar · View at Scopus
24. S. M. Soto, “Human migration and infectious diseases,” Clinical Microbiology and Infection, vol. 15, supplement 1, pp. 26–28, 2009. View at Publisher · View at Google Scholar · View at Scopus
25. J. J. Amon, R. Devasia, G. Xia et al., “Molecular epidemiology of foodborne hepatitis A outbreaks in the United States, 2003,” Journal of Infectious Diseases, vol. 192, no. 8, pp. 1323–1330, 2005. View at Publisher · View at Google Scholar · View at Scopus
26. M. Varia, S. Wilson, S. Sarwal et al., “Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada,” Canadian Medical Association Journal, vol. 169, no. 4, pp. 285–292, 2003. View at Scopus
27. J. M. Drazen, “Smallpox and bioterrorism,” The New England Journal of Medicine, vol. 346, no. 17, pp. 1262–1263, 2002. View at Publisher · View at Google Scholar · View at Scopus
28. J. Nesmith, “SARS economic impact soared above health costs,” The Atlanta Journal-Constitution. In press.
29. R. D. Smith and T. Sommers, “Assessing the economic impact of public health emergencies in international concern: the case of SARS. Globalization, trade and heath working papers series,” Geneva, Switzerland, World Health Organization, 2003.
30. R. D. Smith, “Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management,” Social Science and Medicine, vol. 63, no. 12, pp. 3113–3123, 2006. View at Publisher · View at Google Scholar · View at Scopus
31. M. I. Meltzer, N. J. Cox, and K. Fukuda, “The economic impact of pandemic influenza in the United States: priorities for intervention,” Emerging Infectious Diseases, vol. 5, no. 5, pp. 659–671, 1999. View at Scopus
32. W. McKibbin and D. Sidorenko, “Global macroeconomic consequences of pandemic influenza,” ACERH Research Forum, The University of Queensland Brisbane, 2006.
33. J. R. Coleman, D. Papamichail, S. Skiena, B. Futcher, E. Wimmer, and S. Mueller, “Virus attenuation by genome-scale changes in codon pair bias,” Science, vol. 320, no. 5884, pp. 1784–1787, 2008. View at Publisher · View at Google Scholar · View at Scopus
34. S. Mueller, J. R. Coleman, D. Papamichail et al., “Live attenuated influenza virus vaccines by computer-aided rational design,” Nature Biotechnology, vol. 28, no. 7, pp. 723–726, 2010. View at Publisher · View at Google Scholar
35. E. Wimmer, S. Mueller, T. M. Tumpey, and J. K. Taubenberger, “Synthetic viruses: a new opportunity to understand and prevent viral disease,” Nature Biotechnology, vol. 27, no. 12, pp. 1163–1172, 2009. View at Publisher · View at Google Scholar · View at Scopus
36. H. Bügl, J. P. Danner, R. J. Molinari et al., “DNA synthesis and biological security,” Nature Biotechnology, vol. 25, no. 6, pp. 627–629, 2007. View at Publisher · View at Google Scholar · View at Scopus
37. GENEART, GENEART Synthesizes Genes for Swine Flu Vaccine in Record Speed, Munich Germany: GENEART, 2009.
38. S. S. Kim, L. F. Peng, W. Lin et al., “A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication,” Gastroenterology, vol. 132, no. 1, pp. 311–320, 2007. View at Publisher · View at Google Scholar · View at Scopus
39. Y. S. Kim, Y. H. Lee, H. S. Kim et al., “Development of patatin knockdown potato tubers using RNA interference (RNAi) technology, for the production of human-therapeutic glycoproteins,” BMC Biotechnology, vol. 8, article 36, 2008. View at Publisher · View at Google Scholar · View at Scopus
40. A. P. McCaffrey, H. Nakai, K. Pandey et al., “Inhibition of hepatitis B virus in mice by RNA interference,” Nature Biotechnology, vol. 21, no. 6, pp. 639–644, 2003. View at Publisher · View at Google Scholar · View at Scopus
41. D. Palliser, D. Chowdhury, Q. Y. Wang et al., “An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection,” Nature, vol. 439, no. 7072, pp. 89–94, 2006. View at Publisher · View at Google Scholar · View at Scopus
42. A. V. Paul, E. Rieder, . Dong Wook Kim, J. H. Van Boom, and E. Wimmer, “Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg,” Journal of Virology, vol. 74, no. 22, pp. 10359–10370, 2000. View at Publisher · View at Google Scholar · View at Scopus
43. E. A. Emini, J. Leibowitz, and D. C. Diamond, “Recombinants of Mahoney and Sabin strain poliovirus type 1: analysis of in vitro phenotypic markers and evidence that resistance to guanidine maps in the nonstructural proteins,” Virology, vol. 137, no. 1, pp. 74–85, 1984.
44. N. De Jesus, D. Franco, A. Paul, E. Wimmer, and J. Cello, “Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence,” Journal of Virology, vol. 79, no. 22, pp. 14235–14243, 2005. View at Publisher · View at Google Scholar · View at Scopus
45. J. Goudsmit, A. De Ronde, D. D. Ho, and A. S. Perelson, “Human immunodeficiency virus fitness in vivo: calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase,” Journal of Virology, vol. 70, no. 8, pp. 5662–5664, 1996. View at Scopus
46. R. K. Naz and P. Dabir, “Peptide vaccines against cancer, infectious diseases, and conception,” Frontiers in Bioscience, vol. 12, no. 5, pp. 1833–1844, 2007. View at Publisher · View at Google Scholar · View at Scopus
47. W. Li, X. Hu, L. Liu, H. Chen, and R. Zhou, “Induction of protective immune response against Streptococcus suis serotype 2 infection by the surface antigen HP0245,” FEMS Microbiology Letters, vol. 2010, pp. 1574–6968, 2011.
48. T. H. Ottenhoff, T. M. Doherty, J. T. Dissel, et al., “First in humans: a new molecularly defined vaccine shows excellent safety and strong induction of long-lived Mycobacterium tuberculosis-specific Th1-cell like responses,” Human Vaccines, vol. 6, no. 12, 2010.
49. C. Sun, Y. Zhang, Y. Liu, M. Zhang, and L. Chen, “Enhancement of immunogenicity of replication-defective adenovirus-based human immunodeficiency virus vaccines in rhesus monkeys,” AIDS Research and Human Retroviruses. In press.
50. C. Y. Teng, J. B. Millar, N. Grinshtein, J. Bassett, J. Finn, and J. L. Bramson, “T-cell immunity generated by recombinant adenovirus vaccines,” Expert Review of Vaccines, vol. 6, no. 3, pp. 347–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
51. T. Shiratsuchi, U. Rai, A. Krause, S. Worgall, and M. Tsuji, “Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice,” Journal of Clinical Investigation, vol. 120, no. 10, pp. 3688–3701, 2010. View at Publisher · View at Google Scholar
52. S. Mueller, E. Wimmer, and J. Cello, “Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event,” Virus Research, vol. 111, no. 2, pp. 175–193, 2005. View at Publisher · View at Google Scholar · View at Scopus
53. J. M. Coffin, “Attenuation by a thousand cuts,” The New England Journal of Medicine, vol. 359, no. 21, pp. 2283–2285, 2008. View at Publisher · View at Google Scholar · View at Scopus