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Journal of Pathogens
Volume 2011 (2011), Article ID 826169, 6 pages
http://dx.doi.org/10.4061/2011/826169
Research Article

Pediatric Patients with Intravascular Devices: Polymicrobial Bloodstream Infections and Risk Factors

1Department of Pediatrics, Emma Childrens Hospital, Academic Medical Center, P.O. Box 22700, 1100 DD Amsterdam, The Netherlands
2Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
3Division of Hematology-Oncology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
4Division of Pharmacy, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA

Received 4 July 2010; Revised 1 January 2011; Accepted 15 February 2011

Academic Editor: Cormac G. M. Gahan

Copyright © 2011 Wes Onland et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. J. de Jonge, K. H. Polderman, and R. J. B. J. Gemke, “Central venous catheter use in the pediatric patient: mechanical and infectious complications,” Pediatric Critical Care Medicine, vol. 6, no. 3, pp. 329–339, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. P. Eggimann, H. Sax, and D. Pittet, “Catheter-related infections,” Microbes and Infection, vol. 6, no. 11, pp. 1033–1042, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. M. Knippschild, E. N. Schmid, M. Uppenkamp et al., “Infection by alcaligenes xylosoxidans subsp. xylosoxidans in neutropenic patients,” Oncology, vol. 53, no. 3, pp. 258–262, 1996. View at Scopus
  4. E. Castagnola, I. Caviglia, A. Pistorio et al., “Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution,” European Journal of Cancer, vol. 41, no. 10, pp. 1439–1445, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. R. Haupt, M. Romanengo, T. Fears, C. Viscoli, and E. Castagnola, “Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution,” European Journal of Cancer, vol. 37, no. 18, pp. 2413–2419, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Fratino, A. C. Molinari, S. Parodi et al., “Central venous catheter-related complications in children with oncological/hematological diseases: an observational study of 418 devices,” Annals of Oncology, vol. 16, no. 4, pp. 648–654, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. K. V. I. Rolston, G. P. Bodey, and A. Safdar, “Polymicrobial infection in patients with cancer: an underappreciated and underreported entity,” Clinical Infectious Diseases, vol. 45, no. 2, pp. 228–233, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. W. A. Bonadio, “Polymicrobial bacteremia in children. An 11-year experience,” American Journal of Diseases of Children, vol. 142, no. 11, pp. 1158–1160, 1988. View at Scopus
  9. G. T. Frommell and J. K. Todd, “Polymicrobial bacteremia in pediatric patients,” American Journal of Diseases of Children, vol. 138, no. 3, pp. 266–269, 1984. View at Scopus
  10. D. Sutter, D. Stagliano, L. Braun et al., “Polymicrobial bloodstream infection in pediatric patients: risk factors, microbiology, and antimicrobial management,” Pediatric Infectious Disease Journal, vol. 27, no. 5, pp. 400–405, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. K. J. Downes, J. P. Metlay, L. M. Bell, K. L. McGowan, M. R. Elliott, and S. S. Shah, “Polymicrobial bloodstream infections among children and adolescents with central venous catheters evaluated in ambulatory care,” Clinical Infectious Diseases, vol. 46, no. 3, pp. 387–394, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. M. Nørgaard, H. Larsson, G. Pedersen, H. C. Schønheyder, and H. T. Sørensen, “Risk of bacteraemia and mortality in patients with haematological malignancies,” Clinical Microbiology and Infection, vol. 12, no. 3, pp. 217–223, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. D. Pittet, N. Li, and R. P. Wenzel, “Association of secondary and polymicrobial nosocomial bloodstream infections with higher mortality,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 12, no. 11, pp. 813–819, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Onland, C. E. Shin, S. Fustar, T. Rushing, and W. Y. Wong, “Ethanol-lock technique for persistent bacteremia of long-term intravascular devices in pediatric patients,” Archives of Pediatrics and Adolescent Medicine, vol. 160, no. 10, pp. 1049–1053, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. L. A. Mermel, B. M. Farr, R. J. Sherertz et al., “Guidelines for the management of intravascular catheter-related infections,” Clinical Infectious Diseases, vol. 32, pp. 1249–1272, 2001.
  16. I. I. Raad and H. A. Hanna, “Intravascular catheter-related infections: new horizons and recent advances,” Archives of Internal Medicine, vol. 162, no. 8, pp. 871–878, 2002. View at Scopus
  17. C. Viscoli, E. Castagnola, M. Giacchino et al., “Bloodstream infections in children with cancer: a multicentre surveillance study of the Italian Association of Paediatric Haematology and Oncology,” European Journal of Cancer, vol. 35, no. 5, pp. 770–774, 1999. View at Publisher · View at Google Scholar
  18. C. J. Crnich and D. G. Maki, “The promise of novel technology for the prevention of intravascular device-related bloodstream infection—II. Long-term devices,” Clinical Infectious Diseases, vol. 34, no. 10, pp. 1362–1368, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. E. Castagnola, A. C. Molinari, G. Fratino, and C. Viscoli, “Conditions associated with infections of indwelling central venous catheters in cancer patients: a summary,” British Journal of Haematology, vol. 121, no. 2, pp. 233–239, 2003. View at Scopus
  20. J. S. Groeger, A. B. Lucas, H. T. Thaler et al., “Infectious morbidity associated with long-term use of venous access devices in patients with cancer,” Annals of Internal Medicine, vol. 119, no. 12, pp. 1168–1174, 1993. View at Scopus
  21. S. S. Shah, M. J. Smith, and T. E. Zaoutis, “Device-related infections in children,” Pediatric Clinics of North America, vol. 52, no. 4, pp. 1189–1208, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus