Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses

Table 3

A new categorization of coronaviruses by predicted disorder.

Disorder group	Coronavirus	PID; (M)	PID (N)	Remarks for the group
A	IBV (Avian); HCoV-229E	9.8; 23	56; 56	The most disordered group.; Respiratory transmission.; IBV matrix protein is more ordered than HCoV-229E.
B	SARS-CoV; PEDV; Bovine; Canine (resp.); Bat; HCoV-OC43; HCoV-NL63	8; 8; 7.4; 6.5; 11.5; 7; 11	50; 51; 53; 51; 47; 51; 49	Moderately disordered group.; Some fecal-oral and contact transmissions component. Some respiratory transmission. TGEV has a low nucleocapsid PID but unusually high matrix PID. However, because of the unusually low nucleocapsid disorder, TGEV is placed in group C.
C	TGEV; MHV; Canine (Ent.); HCov-HKU1	14; 8; 8; 4	43; 47; 40; 37	The least disordered group.; Higher levels of fecal-oral and contact; transmission. Lesser levels of the respiratory; transmission component.