Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders
Table 1
Results of the KEGG pathway analysis of the T. gondii host/pathogen interactome (host genes): Immune and defence pathways, Diseases and other infections. The number of genes recovered in each pathway is in brackets and the enrichment value from the CPDB analysis, provided where available, and significant values highlighted in bold.
Number of genes
value
Immune and defence
Cytokine-cytokine receptor interaction
(103)
2.02E − 20
Chemokine signalling pathway
(64)
3.19E − 09
Toll-like receptor signalling pathway
(52)
9.24E − 17
Phagosome
(47)
1.02E − 05
Natural killer cell mediated cytotoxicity
(46)
2.73E − 07
T cell receptor signalling pathway
(45)
1.52E − 10
Hematopoietic cell lineage
(42)
1.52E − 12
Leukocyte transendothelial migration
(36)
0.000149
NOD-like receptor signalling pathway
(34)
9.21E − 14
Fc epsilon RI signalling pathway
(29)
0.000764
Fc gamma R-mediated phagocytosis
(29)
0.00115
Complement and coagulation cascades
(28)
5.80E − 07
B cell receptor signalling pathway
(28)
1.01E − 05
Lysosome
(27)
Antigen processing and presentation
(26)
5.34E − 05
Salivary secretion
(26)
Adipocytokine signalling pathway
(25)
0.000221
RIG-I-like receptor signalling pathway
(23)
0.000354
Cytosolic DNA-sensing pathway
(22)
0.000106
Intestinal immune network for IgA production
(22)
7.87E − 07
Diseases
Pathways in cancer
(94)
2.67E − 08
Transcriptional misregulation in cancer
(52)
3.32E − 06
Prostate cancer
(34)
6.94E − 06
Small cell lung cancer
(31)
4.04E − 06
Colorectal cancer
(23)
3.33E − 05
Pancreatic cancer
(21)
0.0019
Acute myeloid leukaemia
(21)
8.14E − 05
Chronic myeloid leukaemia
(20)
0.00747
Glioma
(19)
0.00964
Renal cell carcinoma
(17)
Endometrial cancer
(16)
0.0048
Non-small cell lung cancer
(15)
Melanoma
(15)
Bladder cancer
(14)
0.00364
Neurological
Alzheimer's disease
(52)
2.02E − 05
Huntington's disease
(34)
Amyotrophic lateral sclerosis (ALS)
(30)
7.94E − 10
Parkinson's disease
(27)
Prion diseases
(22)
2.26E − 08
Autoimmune and atopicdiseases
Systemic lupus erythematosus
(45)
2.48E − 06
Rheumatoid arthritis
(44)
1.26E − 12
Type I diabetes mellitus
(25)
1.11E − 08
Allograft rejection
(23)
1.56E − 09
Autoimmune thyroid disease
(22)
1.62E − 05
Graft-versus-host disease
(21)
3.63E − 06
Asthma
(14)
0.00422
Primary immunodeficiency
(13)
0.00168
Cardiac
Viral myocarditis
(31)
1.24E − 08
Dilated cardiomyopathy
(27)
0.00109
Hypertrophic cardiomyopathy (HCM)
(25)
0.00164
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
