Table 5: Significantly enriched KEGG pathways within the overlapping interactome/susceptibility gene datasets (Immune related, other diseases and infections). values from the CPDB analysis are provided after each pathway description.

Immune and defenceDiseasesOther infections

ADHDNoneNoneNone

AutismIntestinal immune network for IgA production 0.00138
Hematopoietic cell lineage 0.00196
T cell receptor signalling pathway 0.00439
Fc epsilon RI signalling pathway 0.00838
Dilated cardiomyopathy 0.000293
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.000899
Hypertrophic cardiomyopathy (HCM) 0.00151
Viral myocarditis 0.00548
Leishmaniasis 0.00605

AnorexiaNoneNoneNone

Childhood obesityIntestinal immune network for IgA production 0.00417
NOD-like receptor signalling pathway 0.00604
Graft-versus-host disease 0.0000725
Type I diabetes mellitus 0.0000837
Transcriptional misregulation in cancer 0.000397
Rheumatoid arthritis 0.000774
Allograft rejection 0.0025
Type II diabetes mellitus 0.00417
Alzheimer’s disease 0.00426
Chagas disease (American trypanosomiasis) 0.00114
African trypanosomiasis 0.00223
Malaria 0.0047
Legionellosis 0.00544
Herpes simplex infection 0.0056
Pertussis 0.00968

DepressionCytokine-cytokine receptor interaction 0.0000494
NOD-like receptor signalling pathway 0.000203
Hematopoietic cell lineage 0.000998
Rheumatoid arthritis 0.000006
Graft-versus-host disease 0.0000516
Alzheimer’s disease 0.000173
Allograft rejection 0.000845
Leishmaniasis 0.0000000000696
Malaria 0.000000000132
African trypanosomiasis 0.000000000337
Intestinal immune network for IgA production 0.00181
T cell receptor signalling pathway 0.00199
Antigen processing and presentation 0.00665
Fc epsilon RI signalling pathway 0.00741
Type I diabetes mellitus 0.00131
Amyotrophic lateral sclerosis (ALS) 0.00215
Pathways in cancer 0.006
Hypertrophic cardiomyopathy (HCM) 0.00848
Small cell lung cancer 0.00965
Chagas disease (American trypanosomiasis) 0.00000000199
Tuberculosis 0.0000000149
Amoebiasis 0.0000000505
Legionellosis 0.00000786
    Influenza A 0.0000249
Herpes simplex infection 0.0000333
Pertussis 0.0000338
Toxoplasmosis 0.0000548
Salmonella infection 0.000916
HTLV-I infection 0.00202
Measles 0.00463

Bipolar disorderT cell receptor signalling pathway 0.0000000071
NOD-like receptor signalling pathway 0.0000794
Cytokine-cytokine receptor interaction 0.000951
Antigen processing and presentation 0.00275
Fc epsilon RI signalling pathway 0.00317
Natural killer cell mediated cytotoxicity 0.00379
Toll-like receptor signalling pathway 0.00784
Prostate cancer 0.0000601
Pathways in cancer 0.000895
Osteoclast differentiation 0.00000583
Amyotrophic lateral sclerosis (ALS) 0.0000424
Rheumatoid arthritis 0.0000681
Prion diseases 0.000142
Graft-versus-host disease 0.000266
Alzheimer’s disease 0.000268
Allograft rejection 0.00283
Type I diabetes mellitus 0.00435
Malaria 0.000000108
Tuberculosis 0.000000925
Chagas disease (American trypanosomiasis) 0.00000122
African trypanosomiasis 0.00000646
Measles 0.0000734
HTLV-I infection 0.000178
Influenza A 0.000371
Amoebiasis 0.00132
Leishmaniasis 0.00226
Pertussis 0.0025
Herpes simplex infection 0.00273
Toxoplasmosis 0.00368
Legionellosis 0.00867

SchizophreniaCytokine-cytokine receptor interaction 0.000000000286
T cell receptor signalling pathway 0.000000000429
Type I diabetes mellitus 0.00000000983
Allograft rejection 0.0000000512
Graft-versus-host
Leishmaniasis 0.0000000000322
Tuberculosis 0.000000000102
Pertussis 0.000000000705
NOD-like receptor signalling pathway 0.0000216
Hematopoietic cell lineage 0.0000452
Fc epsilon RI signalling pathway 0.000161
Adipocytokine signalling pathway 0.00053
Intestinal immune network for IgA production 0.000682
disease 0.000000121
Rheumatoid arthritis 0.00000747
Amyotrophic lateral sclerosis (ALS) 0.000009
Asthma 0.00007
Autoimmune thyroid disease 0.0001
Alzheimer’s disease 0.0007
African trypanosomiasis 0.000000032
Chagas disease (American trypanosomiasis) 0.000000038
HTLV-I infection 0.000000319
Salmonella infection 0.000000504
Toll-like receptor signalling pathway 0.000773
Antigen processing and presentation 0.000887
Cytosolic DNA-sensing pathway 0.00218
Natural killer cell mediated cytotoxicity 0.00387
RIG-I-like receptor signalling pathway 0.00395
B cell receptor signalling pathway 0.00472
Systemic lupus erythematosus 0.0009
Transcriptional misregulation in cancer 0.001
Prion diseases 0.001
Prostate cancer 0.002
Pathways in cancer 0.003
Acute myeloid leukaemia 0.0099
Measles 0.000000634
Legionellosis 0.00000129
Influenza A 0.0000017
Toxoplasmosis 0.00000446
Herpes simplex infection 0.0000156
Amoebiasis 0.0000259
Malaria 0.000099
Staphylococcus aureus infection 0.000152
Viral myocarditis 0.00372

Multiple sclerosisCytokine-cytokine receptor interaction 1.02E28
Toll-like receptor signalling pathway 0.000000000000000132
Allograft rejection 0.000000000000000147
Type I diabetes mellitus 0.0000000000000549
Rheumatoid arthritis
Chagas disease (American trypanosomiasis) Influenza A Toxoplasmosis
Chemokine signalling pathway 0.000000000000747
Intestinal immune network for IgA production 0.000000000007
T cell receptor signalling pathway 0.0000000000237
0.000000000000153
Graft-versus-host disease 0.0000000000336
Autoimmune thyroid disease 0.000000000425
Pathways in cancer 0.0000000102
NOD-like receptor signalling pathway 0.0000000000639
Hematopoietic cell lineage 0.000000000469
Systemic lupus erythematosus 0.000000625
Prion diseases 0.00000316
Alzheimer’s disease 0.00000422
Pertussis 0.000000000000006
Herpes simplex infection 0.0000000000000315
Natural killer cell mediated cytotoxicity 0.00000058
RIG-I-like receptor signalling pathway 0.00000188
Transcriptional misregulation in cancer 0.00000875
Asthma 0.0000253
Small cell lung cancer 0.000078
African trypanosomiasis 0.00000000000585
Malaria 0.0000000000143
Primary immunodeficiency 0.00000316
Antigen processing and presentation 0.0000325
Leukocyte transendothelial migration 0.0000719
Colorectal cancer 0.0000921
Bladder cancer 0.000135
Amyotrophic lateral sclerosis (ALS) 0.000341
Prostate cancer 0.00067
Amoebiasis 0.0000000000237
Legionellosis 0.0000000000346
Viral myocarditis 0.0000000089
Salmonella infection 0.0000000677
Cytosolic DNA-sensing pathway 0.0000921
Complement and coagulation cascades 0.00927
Adipocytokine signalling pathway 0.00927
Pancreatic cancer 0.00147
Chronic myeloid leukaemia 0.00177
Endometrial cancer 0.00339
Acute myeloid leukaemia 0.00473
Thyroid cancer 0.00487
HTLV-I infection 0.000000512
Hepatitis C 0.000000538
Staphylococcus aureus infection 0.00000371
Shigellosis 0.000786
Epithelial cell signalling in Helicobacter pylori infection 0.00882

Alzheimer’s Hematopoietic cell lineage 0.000000276
Complement and coagulation cascades 0.00000049
Toll-like receptor signalling pathway 0.000000982
NOD-like receptor signalling pathway 0.000002
Cytokine-cytokine receptor interaction 0.000003
Rheumatoid arthritis 0.0000000000000007
Alzheimer’s disease 0.000000013
Graft-versus-host disease 0.0000035
Type I diabetes mellitus 0.000076
Prion diseases 0.000442
Transcriptional misregulation in cancer 0.00049
Malaria 6.05E 17
Chagas disease (American trypanosomiasis) 0.00000000004
Pertussis 0.000000000204
Leishmaniasis 0.00000000283
Tuberculosis 0.00000000325
Legionellosis 0.00000000407
Cytosolic DNA-sensing pathway 0.000436
Phagosome 0.00098
Intestinal immune network for IgA production 0.00148
Adipocytokine signalling pathway 0.00558
Allograft rejection 0.000549
Hypertrophic cardiomyopathy (HCM) 0.00165
Pathways in cancer 0.00205
Systemic lupus erythematosus 0.00281
Influenza A 0.0000000246
African trypanosomiasis 0.0000000547
Amoebiasis 0.000000126
Salmonella infection 0.000000226

Parkinson’sNOD-like receptor signalling pathway 0.00000539
Toll-like receptor signalling pathway 0.00000543
Hematopoietic cell lineage 0.0000417
Cytokine-cytokine receptor interaction 0.000153
T cell receptor signalling pathway 0.00123
Intestinal immune network for IgA production 0.00125
Cytosolic DNA-sensing pathway 0.00261
Complement and coagulation cascades 0.00354
Antigen processing and presentation 0.00465
Chemokine signalling pathway 0.00977
Rheumatoid arthritis 0.000000131
Graft-versus-host disease 0.000000932
Type I diabetes mellitus 0.00000119
Asthma 0.00031
Systemic lupus erythematosus 0.000327
Prion diseases 0.000491
Allograft rejection 0.00058
Alzheimer’s disease 0.000792
Parkinson’s disease 0.00261
Pathways in cancer 0.00315
Hypertrophic cardiomyopathy (HCM) 0.00594
Small cell lung cancer 0.00677
Prostate cancer 0.00721
Measles 0.000463
Toxoplasmosis 0.000463
Herpes simplex infection 0.000578
Staphylococcus aureus infection 0.00246
Pertussis 0.000000000000612
Tuberculosis 0.00000000000987
Leishmaniasis 0.0000000254
Influenza A 0.0000000563
Malaria 0.000000086
Salmonella infection 0.0000000885
Legionellosis 0.000000137
Chagas disease (American trypanosomiasis) 0.00000033
Amoebiasis 0.000000376
African trypanosomiasis 0.000000412
Staphylococcus aureus infection 0.0000997
Measles 0.000305
Toxoplasmosis 0.000305
Hepatitis C 0.00291
HTLV-I infection 0.00604
Herpes simplex infection 0.00858